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"all": [ [ "AAGAB", " genetic interference ", "23284306", " \"synthetic growth defect sensu biogrid \" ", "1278703" ], [ "AARS", " affinity chromatography technology ", "32807901", " physical association ", "2976333" ], [ "AASDH", " bioid ", "38580884", " physical association ", "3713332" ], [ "AATF", " affinity chromatography technology ", "25996291", " physical association ", "2596577" ], [ "ABCA12", " genetic interference ", "24378760", " \"synthetic lethality sensu biogrid \" ", "3477142" ], [ "ABCF1", " affinity chromatography technology ", "32807901", " physical association ", "2976331" ], [ "ABCF2", " affinity chromatography technology ", "32807901", " physical association ", "2976524" ], [ "ABHD16B", " genetic interference ", "30862715", " \"negative genetic interaction sensu biogrid \" ", "2872157" ], [ "ABL1", " affinity chromatography technology ", "17992189", " physical association ", "3731298" ], [ "ABR", " affinity chromatography technology ", "23443559", " physical association ", "954635" ], [ "ABR", " affinity chromatography technology ", "32807901", " physical association ", "2976577" ], [ "ACACA", " affinity chromatography technology ", "31152661", " physical association ", "2659065" ], [ "ACAD10", " affinity chromatography technology ", "32807901", " physical association ", "2976787" ], [ "ACADM", " affinity chromatography technology ", "32807901", " physical association ", "2976655" ], [ "ACBD3", " affinity chromatography technology ", "32807901", " physical association ", "2976206" ], [ "ACKR3", " two hybrid ", "27229929", " direct interaction ", "2380967" ], [ "ACLY", " affinity chromatography technology ", "32807901", " physical association ", "2976172" ], [ "ACO2", " affinity chromatography technology ", "35140242", " physical association ", "3321365" ], [ "ACSL4", " affinity chromatography technology ", "23443559", " physical association ", "954636" ], [ "ACTA2", " affinity chromatography technology ", "23443559", " physical association ", "954638" ], [ "ACTB", " affinity chromatography technology ", "23443559", " physical association ", "954641" ], [ "ACTB", " affinity chromatography technology ", "25144556", " physical association ", "1029304" ], [ "ACTB", " affinity chromatography technology ", "35474131", " physical association ", "3638467" ], [ "ACTBL2", " affinity chromatography technology ", "25144556", " physical association ", "1029305" ], [ "ACTG1", " affinity chromatography technology ", "32807901", " physical association ", "2976274" ], [ "ACTL6A", " affinity chromatography technology ", "17878219", " physical association ", "658087" ], [ "ACTN4", " affinity chromatography technology ", "32807901", " physical association ", "2976565" ], [ "ACVR1C", " genetic interference ", "23284306", " \"synthetic growth defect sensu biogrid \" ", "1278704" ], [ "ADAM28", " genetic interference ", "23284306", " \"synthetic growth defect sensu biogrid \" ", "1278705" ], [ "ADAM9", " affinity chromatography technology ", "32807901", " physical association ", "2976606" ], [ "ADAR", " affinity chromatography technology ", "32807901", " physical association ", "2976389" ], [ "ADCK5", " affinity chromatography technology ", "32807901", " physical association ", "2976176" ], [ "ADD1", " affinity chromatography technology ", "32807901", " physical association ", "2976610" ], [ "ADD3", " affinity chromatography technology ", "32807901", " physical association ", "2976217" ], [ "ADH5", " affinity chromatography technology ", "20308539", " physical association ", "438249" ], [ "ADNP", " affinity chromatography technology ", "32807901", " physical association ", "2976456" ], [ "ADNP", " bioid ", "34795231", " physical association ", "3338713" ], [ "ADO", " genetic interference ", "38580884", " \"synthetic rescue sensu biogrid \" ", "3712957" ], [ "AGBL2", " affinity chromatography technology ", "20308539", " physical association ", "438250" ], [ "AGGF1", " affinity chromatography technology ", "33069768", " physical association ", "3196702" ], [ "AGO1", " affinity chromatography technology ", "20308539", " physical association ", "438259" ], [ "AGO1", " affinity chromatography technology ", "32807901", " physical association ", "2976587" ], [ "AGO2", " affinity chromatography technology ", "20308539", " physical association ", "438260" ], [ "AGO2", " affinity chromatography technology ", "32807901", " physical association ", "2976574" ], [ "AGPAT6", " affinity chromatography technology ", "32807901", " physical association ", "2976649" ], [ "AGT", " two hybrid ", "22416758", " direct interaction ", "643047" ], [ "AGTPBP1", " affinity chromatography technology ", "32807901", " physical association ", "2976178" ], [ "AGTRAP", " affinity chromatography technology ", "32807901", " physical association ", "2976561" ], [ "AHCTF1", " affinity chromatography technology ", "32807901", " physical association ", "2976836" ], [ "AHCY", " affinity chromatography technology ", "34591612", " physical association ", "3496461" ], [ "AHCY", " affinity chromatography technology ", "37438558", " physical association ", "3739025" ], [ "AIFM1", " affinity chromatography technology ", "32807901", " physical association ", "2976346" ], [ "AIFM2", " affinity chromatography technology ", "23443559", " physical association ", "954647" ], [ "AIMP2", " affinity chromatography technology ", "18695251", " physical association ", "327648" ], [ "AIMP2", " pull down ", "18695251", " direct interaction ", "327649" ], [ "AIMP2", " two hybrid ", "18695251", " direct interaction ", "327650" ], [ "AIP", " bioid ", "38580884", " physical association ", "3713457" ], [ "AIPL1", " affinity chromatography technology ", "27173435", " physical association ", "2332108" ], [ "AKAP12", " affinity chromatography technology ", "23443559", " physical association ", "954648" ], [ "AKAP5", " two hybrid ", "31182485", " direct interaction ", "2878990" ], [ "AKAP8L", " affinity chromatography technology ", "32807901", " 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"CHEMBL176045", "" ], [ "KINASE", "", "GNF-PF-3416", 0.05, "CHEMBL579550", "" ], [ "KINASE", "", "VX-970", 0.02, "CHEMBL3989870", "" ], [ "KINASE", "", "FURAZOLIDONE", 0.07, "CHEMBL1103", "" ], [ "KINASE", "", "GNF-PF-3012", 0.07, "CHEMBL582715", "" ], [ "KINASE", "", "GNF-PF-2968", 0.05, "CHEMBL582473", "" ], [ "KINASE", "", "QPI-1002", 0.15, "CHEMBL4297574", "" ], [ "KINASE", "", "AMOXAPINE", 0.01, "CHEMBL1113", "" ], [ "KINASE", "", "SJ000124275", 0.04, "CHEMBL602150", "" ], [ "KINASE", "", "PACLITAXEL", 0.01, "CHEMBL428647", 16459017 ], [ "KINASE", "", "CID 4101591", 0.01, "CHEMBL428789", "" ], [ "KINASE", "", "PANITUMUMAB", 0.01, "CHEMBL1201827", 28514312 ], [ "KINASE", "", "STREPTONIGRIN", 0.01, "CHEMBL11417", 12027749 ], [ "KINASE", "", "SELICICLIB", 0.05, "CHEMBL14762", "22862161,26826118" ], [ "KINASE", "", "OSM-S-85", 0.07, "CHEMBL1494650", "" ], [ "KINASE", "", "PENTACHLOROPHENOL", 0.01, "CHEMBL75967", "" ], [ "KINASE", "", "SANGUINARINE SULFATE", 0.01, "CHEMBL1565133", "" ], [ "KINASE", "", "CLEMASTINE", 0.02, "CHEMBL1626", "" ], [ "KINASE", "", "ZIRAM", 0.01, "CHEMBL1519327", "" ], [ "KINASE", "", "CID 739615", 0.02, "CHEMBL260560", "" ] ], "category": "KINASE", "chembl": "CHEMBL3186011", "interaction": null, "name": "APR-246", "pmid": "22965953,21239882,21415220,26086967,27179933", "score": 1.04 }, "encode_tfbs": null, "ensembl_regulatory_build": null, "esm1b": { "all": [ [ "ENST00000504937", -9.102, 0.71033, "Deleterious", "", "" ], [ "ENST00000610292", -9.454, 0.71033, "Deleterious", "", "" ], [ "ENST00000269305", -9.528, 0.71033, "Deleterious", "", "" ], [ "ENST00000620739", -9.454, 0.71033, "Deleterious", "", "" ], [ "ENST00000445888", -9.528, 0.71033, "Deleterious", "", "" ], [ "ENST00000619485", -9.454, 0.71033, "Deleterious", "", "" ] ], "bp4_benign": null, "pp3_pathogenic": null, "prediction": "Deleterious", "rankscore": 0.71033, "score": -9.528, "transcript": "ENST00000445888;ENST00000269305" }, "ess_gene": { "ess_gene": "E", "ess_gene_crispr": "N", "ess_gene_crispr2": "S", "ess_gene_gene_trap": "N", "indispensability_pred": "E", "indispensability_score": "1" }, "fathmm": null, "fathmm_mkl": { "bp4_pathogenic": null, "fathmm_mkl_coding_pred": "Damaging", "fathmm_mkl_coding_rankscore": 0.9319299999999999, "fathmm_mkl_coding_score": 0.9923299999999999, "fathmm_mkl_group": "AEFBI", "pp3_pathogenic": "Supporting" }, "fathmm_xf_coding": { "bp4_pathogenic": null, "fathmm_xf_coding_pred": "Damaging", "fathmm_xf_coding_rankscore": 0.7985300000000001, "fathmm_xf_coding_score": 0.8752270000000001, "pp3_pathogenic": "Supporting" }, "fitcons": { "fitcons_coding_pred": 0, "fitcons_coding_rankscore": 0.73137, "fitcons_coding_score": 0.706548 }, "genehancer": null, "gerp": { "bp4_benign": null, "bp4_pathogenic": null, "gerp_nr": 5.43, "gerp_rs": 5.43, "gerp_rs_rank": 0.78925 }, "geuvadis": null, "ghis": { "ghis": 0.599240746 }, "gnomad": null, "gnomad3": null, "go": { "bpo_id": "GO:0000122;GO:0002244;GO:0006289;GO:0006355;GO:0006357;GO:0006914;GO:0006915;GO:0006974;GO:0006979;GO:0006983;GO:0007265;GO:0007623;GO:0008104;GO:0008285;GO:0008340;GO:0009299;GO:0009410;GO:0009411;GO:0010212;GO:0010332;GO:0010628;GO:0012501;GO:0016032;GO:0030308;GO:0030330;GO:0031571;GO:0032211;GO:0033209;GO:0034644;GO:0042149;GO:0042771;GO:0042981;GO:0043065;GO:0043066;GO:0043153;GO:0045815;GO:0045892;GO:0045893;GO:0045899;GO:0045944;GO:0046677;GO:0048147;GO:0048511;GO:0048512;GO:0048539;GO:0051053;GO:0051097;GO:0051262;GO:0051726;GO:0060218;GO:0060333;GO:0062100;GO:0065003;GO:0070059;GO:0070245;GO:0071456;GO:0071466;GO:0071479;GO:0071480;GO:0072331;GO:0072332;GO:0072717;GO:0090200;GO:0090398;GO:0090399;GO:0090403;GO:0097190;GO:0097193;GO:0097252;GO:1900119;GO:1902749;GO:1902895;GO:1903451;GO:1905856;GO:2000379;GO:2000774;GO:2001242;GO:2001244", "bpo_name": "negative regulation of transcription by RNA polymerase II;hematopoietic progenitor cell differentiation;nucleotide-excision repair;regulation of DNA-templated transcription;regulation of transcription by RNA polymerase II;autophagy;apoptotic process;DNA damage response;response to oxidative stress;ER overload response;Ras protein signal transduction;circadian rhythm;intracellular protein localization;negative regulation of cell population proliferation;determination of adult lifespan;mRNA transcription;response to xenobiotic stimulus;response to UV;response to ionizing radiation;response to gamma radiation;positive regulation of gene expression;programmed cell death;viral process;negative regulation of cell growth;DNA damage response, signal transduction by p53 class mediator;mitotic G1 DNA damage checkpoint signaling;negative regulation of telomere maintenance via telomerase;tumor necrosis factor-mediated signaling pathway;cellular response to UV;cellular response to glucose starvation;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;regulation of apoptotic process;positive regulation of apoptotic process;negative regulation of apoptotic process;entrainment of circadian clock by photoperiod;transcription initiation-coupled chromatin remodeling;negative regulation of DNA-templated transcription;positive regulation of DNA-templated transcription;positive regulation of RNA polymerase II transcription preinitiation complex assembly;positive regulation of transcription by RNA polymerase II;response to antibiotic;negative regulation of fibroblast proliferation;rhythmic process;circadian behavior;bone marrow development;negative regulation of DNA metabolic process;negative regulation of helicase activity;protein tetramerization;regulation of cell cycle;hematopoietic stem cell differentiation;type II interferon-mediated signaling pathway;positive regulation of programmed necrotic cell death;protein-containing complex assembly;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;positive regulation of thymocyte apoptotic process;cellular response to hypoxia;cellular response to xenobiotic stimulus;cellular response to ionizing radiation;cellular response to gamma radiation;signal transduction by p53 class mediator;intrinsic apoptotic signaling pathway by p53 class mediator;cellular response to actinomycin D;positive regulation of release of cytochrome c from mitochondria;cellular senescence;replicative senescence;oxidative stress-induced premature senescence;apoptotic signaling pathway;intrinsic apoptotic signaling pathway;oligodendrocyte apoptotic process;positive regulation of execution phase of apoptosis;regulation of cell cycle G2/M phase transition;positive regulation of miRNA transcription;negative regulation of G1 to G0 transition;negative regulation of pentose-phosphate shunt;positive regulation of reactive oxygen species metabolic process;positive regulation of cellular senescence;regulation of intrinsic apoptotic signaling pathway;positive regulation of intrinsic apoptotic signaling pathway", "cco_id": "GO:0000785;GO:0005634;GO:0005654;GO:0005667;GO:0005730;GO:0005737;GO:0005739;GO:0005759;GO:0005783;GO:0005813;GO:0005829;GO:0016363;GO:0016604;GO:0016605;GO:0017053;GO:0032991", "cco_name": "chromatin;nucleus;nucleoplasm;transcription regulator complex;nucleolus;cytoplasm;mitochondrion;mitochondrial matrix;endoplasmic reticulum;centrosome;cytosol;nuclear matrix;nuclear body;PML body;transcription repressor complex;protein-containing complex", "mfo_id": "GO:0000976;GO:0000978;GO:0000981;GO:0000987;GO:0001046;GO:0001094;GO:0001223;GO:0001227;GO:0001228;GO:0002020;GO:0002039;GO:0003677;GO:0003682;GO:0003700;GO:0003730;GO:0005507;GO:0005515;GO:0008270;GO:0019899;GO:0030971;GO:0031625;GO:0036310;GO:0042802;GO:0042826;GO:0046872;GO:0046982;GO:0051087;GO:0051721;GO:0061629;GO:0071889;GO:0097371;GO:0097718;GO:0140296;GO:0140677;GO:0140693;GO:1990841", "mfo_name": "transcription cis-regulatory region binding;RNA polymerase II cis-regulatory region sequence-specific DNA binding;DNA-binding transcription factor activity, RNA polymerase II-specific;cis-regulatory region sequence-specific DNA binding;core promoter sequence-specific DNA binding;TFIID-class transcription factor complex binding;transcription coactivator binding;DNA-binding transcription repressor activity, RNA polymerase II-specific;DNA-binding transcription activator activity, RNA polymerase II-specific;protease binding;p53 binding;DNA binding;chromatin binding;DNA-binding transcription factor activity;mRNA 3'-UTR binding;copper ion binding;protein binding;zinc ion binding;enzyme binding;receptor tyrosine kinase binding;ubiquitin protein ligase binding;ATP-dependent DNA/DNA annealing activity;identical protein binding;histone deacetylase binding;metal ion binding;protein heterodimerization activity;protein-folding chaperone binding;protein phosphatase 2A binding;RNA polymerase II-specific DNA-binding transcription factor binding;14-3-3 protein binding;MDM2/MDM4 family protein binding;disordered domain specific binding;general transcription initiation factor binding;molecular function activator activity;molecular condensate scaffold activity;promoter-specific chromatin binding" }, "grasp": null, "gtex": null, "gwas_catalog": null, "intact": { "acts": "AIMP2;AIPL1;ANK2;ANXA3;ANXA7;APOH;APPL1;APTX;AR;ARIH2;ARL3;ARRB1;ASH2L;ATAD3A;ATAD3B;ATF3;ATG7;ATM;ATR;AURKB;AXIN1;BAG1;BAG2;BAG6;BANP;BARD1;BAX;BCL2;BCL2L1;BCL6;BCR;BHLHE40;BLM;BMP1;BMX;BRCA1;BRCA2;BRD7;BTBD2;BTRC;CABLES1;CASP1;CCAR2;CCDC106;CCDC8;CCL18;CCT2;CCT3;CCT4;CCT5;CCT6A;CCT7;CCT8;CDC42;CDK2;CDKN1A;CDKN2A;CDKN2C;CEBPB;CEBPZ;CEP120;CEP128;CEP135;CEP152;CHEK1;CHEK2;CITED1;CLK3;COLGALT1;COP1;COPS4;COX17;CREB1;CREBBP;CRK;CSE1L;CSNK1D;CSNK1E;CSNK2A1;CSNK2A2;CSNK2B;CUL7;CUL9;CXXC1;DAXX;DDX17;DDX5;DKFZp434J046;DLEU1;DLST;DROSHA;DUSP26;DVL2;DYNC1I1;EAF2;EEF2;EGLN3;EGR1;EIF2S2;EP300;ERH;ETS2;FAM173A;FBXO11;FBXW8;FCAMR;FOXA3;FOXB1;FOXC1;FOXG1;FOXJ3;FOXK1;FOXK2;FOXN1;FOXO3;FOXP1;FOXQ1;FOXS1;FXYD6;GADD45A;GFI1;GLI1;GNL3;GNL3L;GPX2;GRB2;GSK3B;GSTM4;GTF2H1;GUSBP1;HDAC1;HDAC2;HDAC3;HDAC8;HERC2;HINFP;HIPK1;HIPK2;HIPK3;HMGB1;HNRNPK;HNRNPUL1;HSP90AA1;HSP90AB1;HSPA1A;HSPA1L;HSPA5;HSPA9;HSPB1;HSPD1;HTT;HUWE1;ICK;IFI16;IKBKB;ING2;ING4;IP6K2;ITCH;JMJD6;JMY;JUN;KAT2B;KAT5;KAT8;KDM1A;KDM4A;KHDRBS1;KIAA0087;KMT2A;KMT2C;KMT2E;KSR1;KSR2;LAMA4;LMNA;LRRK2;MAD2L1BP;MAEA;MAGEA2;MAGEB18;MAGEC2;MAP1B;MAPK1;MAPK11;MAPKAPK5;MDM2;MDM4;MED1;MEN1;MKRN1;MOV10;MPDZ;MPHOSPH6;MPP5;MRPS22;MT1A;MTOR;MYC;NABP1;NAP1L1;NCL;NCOA2;NCOA6;NCOR2;NEDD8;NEIL3;NEURL4;NFATC1;NFYA;NFYB;NIN;NINL;NMT1;NMT2;NOC2L;NOL3;NPAS3;NPM1;NR0B2;NR4A1;NRDC;NT5C2;NUAK1;NUDT16L1;NUMB;OBSL1;OFD1;OLA1;OTUB1;OTUD5;PADI1;PAFAH1B3;PAGR1;PARD3;PARP1;PAXIP1;PBK;PCDHA4;PDHA1;PES1;PHB;PHC3;PHF1;PIAS1;PIAS2;PIAS4;PIN1;PLCG2;PLK1;PLOD3;PML;PNP;POLRMT;PPA1;PPIF;PPM1G;PPP1CA;PPP1CC;PPP1R13B;PPP1R13L;PPP1R15A;PPP2R1A;PPP2R2A;PPP2R5C;PRKAB2;PRKCD;PSMC1;PSMD11;PSMD2;PSMD5;PSME3;PTBP3;PTK2;PYCR3;RAB4A;RABGAP1;RAD51;RANBP9;RAP1B;RASGRF1;RB1;RB1CC1;RBBP5;RBPJ;RBX1;RCC1;RCHY1;RFWD3;RING1;RNASEL;RNF20;RNF40;RPA1;RPA2;RPGRIP1L;RPL5;RPS19BP1;RPS27A;RPS3;RPS7;RRM2B;RYBP;S100A1;S100A2;S100A4;S100A6;S100A8;S100B;SAE1;SAFB;SAFB2;SARS2;SAT1;SCAMP1;SERPINB9;SETD1A;SETD7;SFN;SIN3A;SIRT1;SKP1;SMAD2;SMARCA4;SMARCA5;SMARCAL1;SMARCC1;SMG5;SMG7;SMN1;SMYD2;SNAI1;SNRPN;SOX4;SP1;SPICE1;SREBF1;SREBF2;SRPK1;SSX2IP;STK11;STK4;STUB1;STX5;SULT1E1;SUMO1;SUMO2;SYVN1;TBP;TCF4;TCP1;TDRD12;THAP8;TK1;TMSB4X;TOE1;TOP1MT;TOP3A;TOPORS;TP53;TP53BP1;TP53BP2;TP53TG1;TP63;TPT1;TRAF1;TRIM24;TRIM28;TSPAN10;TSPYL4;TUBB;TUBB2A;TUBB2C;TUBB3;TWIST1;TWIST2;TWNK;UBA1;UBB;UBC;UBE2E1;UBE2I;UBE3A;UFD1;UHRF2;USP11;USP28;USP29;USP39;USP42;USP7;VDR;VRK1;WDR33;WDR48;WDR5;WDR82;WRN;WWOX;XPO1;XRCC1;XRCC6;YTHDC2;YWHAE;YWHAG;YWHAQ;YWHAZ;YY1;YY2;ZCCHC10;ZIC3;ZNF24;ZNF385A;ZNF420", "intact": "RB1[20871633]|RPL5[22653443]|NOC2L[16322561]|RBPJ[26302407]|PSMD5[22653443]|MYC[21150319]|PSMD2[22653443]|DLEU1[16169070]|DDX17[15660129]|MED1[15848166]|DAXX[16845383;14557665;15364927;25241761;21134643]|PRKAB2[27107012]|CSNK2A1[22975381;25241761]|CSNK2A2[22653443]|PRKCD[16377624]|SCAMP1[16713569]|BCR[16169070;25241761]|FCAMR[21988832]|AR[19481544]|WDR82[23870121]|PSME3[18309296]|MAP1B[18656471]|PARD3[22653443]|ATF3[16169070]|TSPYL4[22653443]|PADI1[25402006]|ZNF24[16169070]|PLCG2[25814554]|PCDHA4[16169070]|SFN[20206173;21625211]|ATG7[22499945]|GSTM4[16169070]|BARD1[15782130]|TOE1[19508870]|CREBBP[10823891;9194564;10196247;25314079;19234109;19805293]|JUN[25609649]|PLK1[16753148;19833129;22653443]|SETD1A[23870121]|MAD2L1BP[16169070]|NFATC1[25609649]|NR0B2[22575647]|PHC3[27705803]|MOV10[25609649]|HNRNPK[21821029;23092970]|NMT1[16530191]|SNAI1[20385133]|NMT2[16530191]|FXYD6[16169070]|CDKN1A[16616141;21900206;25241761]|WDR48[19615732]|PHF1[27705803]|SETD7[15525938;21988832;16415881;17108971;17805299;21245319]|ASH2L[23870121;19433796]|SMG7[22653443]|GLI1[25609649]|SMG5[22653443;25609649]|ING4[15251430]|IKBKB[19883646;19196987]|ING2[16782091]|TMSB4X[16169070]|PBK[17482142;20622899]|ANXA7[21900206]|TK1[16169070;21900206]|NINL[26638075]|APPL1[25814554]|OFD1[26638075]|RING1[29187402]|ANXA3[16169070]|SERPINB9[16169070]|NUDT16L1[22653443]|SIRT1[11672523;17964266;12006491;15205477;18235501;18235502;21245319]|GNL3[12464630]|WDR33[16169070]|NCOR2[24449765]|KAT2B[16959611]|TUBB2C[22653443]|TUBB2A[22653443]|TCP1[22653443]|PAFAH1B3[16169070]|RNASEL[25609649]|HTT[10823891]|KIAA0087[16169070]|DLST[29128334]|WRN[11427532;15735006]|FOXS1[25609649]|SULT1E1[16169070]|TP53TG1[16169070]|RPS3[19656744]|STX5[16169070]|CCL18[16169070]|BRD7[20228809;20660729]|RPS27A[22653443]|WWOX[15580310]|EGLN3[26972000]|CDKN2C[16169070]|HSPA1L[17184779;25241761]|CDKN2A[12740913;22653443]|SYVN1[17170702]|GTF2H1[18354501]|HIPK1[12702766]|HIPK3[23602568]|HIPK2[15896780;16212962;21057547]|HINFP[21516116]|RYBP[19098711]|CCDC8[22653443]|PSMC1[22653443]|RFWD3[20173098]|HSPA1A[25241761]|CSE1L[17719542]|CEP120[26638075]|PLOD3[22653443]|SAT1[16169070]|CEP128[26638075]|FOXQ1[25609649]|YY1[25402006]|PPP1CC[17274640]|STK11[21317932]|MAEA[22653443]|YY2[25402006]|TUBB3[22653443]|MEN1[15960975]|PIAS4[11388671]|USP7[11923872;16845383;17268548;21170034;22653443;15916963;16402859;16474402;22056774]|SNRPN[16169070]|CEP135[26638075]|RPS7[17310983]|S100A2[20591429]|FBXW8[22653443;25609649]|S100A1[20591429]|SPICE1[26638075]|UBE2E1[29187402]|VRK1[15542844;24492002;29340707]|POLRMT[25609649]|FBXO11[17098746]|PIAS2[18624398;25241761]|RNF40[19410543]|PIAS1[15133049;25241761]|RBX1[22653443]|FOXP1[25609649]|NCL[22103682]|S100A6[20591429]|ERH[16169070]|MAPKAPK5[17254968]|S100A4[19740107;20591429;23752197]|S100A8[16169070]|CUL9[18230339;22653443;25609649]|KMT2E[21423215]|KHDRBS1[22653443]|CUL7[17298945;22653443;25609649]|BLM[22653443]|KMT2A[15960975]|ARL3[16169070]|KMT2C[19433796]|PHB[16319068;20134482;24380853]|FOXO3[14976264;25241761]|NPAS3[25609649]|RAP1B[21900206]|BAG6[22653443]|BAG2[22653443;25036637]|BTBD2[16169070]|BAG1[25036637]|DVL2[16189514;16713569;27107012]|SAFB2[21130767]|SMYD2[25609649;17805299;21782458]|SMN1[21900206]|MPDZ[22653443]|ZNF420[20713054]|IP6K2[21078964]|RAB4A[16169070]|NRDC[22653443]|BMX[16186805]|EEF2[22653443]|FOXN1[25609649]|COPS4[22653443]|GNL3L[21132010]|BCL6[25402006]|SP1[15710382;21831840]|CDK2[25241761]|MDM2[14704432;8875929;15848166;15144954;16212962;12915590;16845383;11178989;17139261;17159902;17268548;17347673;17310983;17875722;18309296;10196247;18485870;19166840;19098711;19411066;20591429;20708156;21170087;21132010;21988832;21726810;22085928;22575647;22659184;22819825;22510990;22975381;22653443;25241761;23776060;19656744;25609649;16432196;17080083;17438265;17470788;18172499;18316739;19234109;19255450;20173098;21857681;24207125;24667498;29997244]|BCL2[19521340;12667443]|TDRD12[22653443]|PIN1[12397362;21741598;21900206;17906639]|MDM4[15604276;17875722;19521340;20515689;20705607;15916963;25609649;17080083;19255450;24667498]|BCL2L1[16151013;21900206;12667443;14963330;24814347]|PPP1R13B[21513714]|HSP90AB1[22939624]|LRRK2[24725412]|RASGRF1[16753148]|ARRB1[21857681]|TSPAN10[22653443]|PAGR1[19039327]|SUMO1[16732283;19684601;20534433]|SIN3A[10823891;11359905]|PPP1R13L[21513714;17906639;23623661;18275817]|SUMO2[20534433]|WDR5[15960975;23870121;19433796]|GPX2[21988832]|HSP90AA1[21460846]|KSR1[27086506]|TRAF1[22653443]|KSR2[27086506]|DUSP26[20562916]|PTBP3[22575643]|SARS2[22653443]|RRM2B[19015526]|NUMB[18172499]|CRK[25814554]|SSX2IP[26638075]|PPP1R15A[29109149]|CEBPB[16227626]|HDAC2[17805299]|HDAC3[16847267]|UHRF2[21952639]|HDAC1[16959611;20075864;25241761]|CXXC1[23870121]|FOXK2[25609649]|FOXK1[25609649]|RCHY1[17568776;20452352;21988832;19043414]|HDAC8[17721440]|PPM1G[22653443]|CDC42[16169070]|IFI16[11146555;21397192]|RBBP5[15960975;23870121;19433796]|RNF20[19410543]|CEP152[26638075]|FOXJ3[25609649]|CABLES1[11706030]|PML[12915590;21057547;12006491;25241761]|MTOR[19619545]|NIN[26638075]|RAD51[9380510]|CEBPZ[12534345]|STUB1[25036637]|TPT1[21081126;22451927]|SMARCAL1[22653443]|GFI1[23410974]|PPP2R2A[17245430]|CCAR2[18235501]|PNP[16169070]|HERC2[22653443]|KAT5[18485870]|TRIM28[20864041]|PPP2R1A[17245430;25241761]|CHEK2[10724175;15862297;18833288]|CHEK1[16511572]|TRIM24[19556538]|KAT8[16601686;15960975]|RCC1[21900206]|MAGEA2[20864041;16847267]|BTRC[19196987]|TP63[19345189;21741598]|SOX4[19234109]|SKP1[22653443]|SMARCC1[18303029]|ANK2[20195357]|CSNK1D[25241761]|CSNK1E[25241761]|JMJD6[24667498]|NEIL3[25402006]|MT1A[16442532]|THAP8[16169070]|PPA1[16169070]|CSNK2B[22653443]|TP53[16291740;17612295;19339993;21988832;21522129;22653443;14985081;25609649;25402006;16461914;17620598;18087040;19667193;20004160;20159469;20364130;21178074;22972749]|OBSL1[22653443;25609649]|PAXIP1[19433796]|FOXG1[25609649]|TWIST2[22975381]|TWIST1[18504427;22975381;25402006]|NUAK1[21317932]|APOH[18624398]|TP53BP2[8875926;21513714;14985081;18275817]|TP53BP1[11877378;22653443;14985081;17805299;19433796;25579814;25651062;25837623]|MAGEC2[20864041]|BANP[20075864]|EGR1[14744935]|XRCC6[15782130]|GADD45A[21900206]|SMARCA5[25609649]|EAF2[27107012]|XRCC1[15044383]|PYCR3[22653443]|PTK2[15855171;19857493;25241761]|SMARCA4[18303029]|SRPK1[21130767]|ICK[23602568]|CCT6A[22653443]|AIMP2[18695251]|ATM[10864201]|GRB2[22653443]|ATR[16293623]|ZCCHC10[16169070]|CITED1[20227041]|OLA1[22653443]|BRCA1[9926942]|BRCA2[20421506]|XPO1[17268548;18952844]|ARIH2[16169070;22819825]|UFD1[21900206]|CCT3[22653443]|NCOA2[20195357]|SREBF1[22265415]|CCT2[22653443]|PARP1[12898523;14627987;15044383]|NCOA6[19433796]|TUBB[22653443]|MRPS22[22653443]|TOP3A[22653443]|TOPORS[17290218]|SREBF2[22265415]|FOXC1[25609649]|RABGAP1[22653443]|DKFZp434J046[22653443]|NEDD8[22653443]|CCDC106[16169070;20159018]|NOL3[18087040]|PES1[25609649]|LMNA[29568061]|CCT8[22653443]|CCT7[22653443]|CCT5[16169070;22653443]|DYNC1I1[16616141]|CCT4[22653443]|FOXB1[25609649]|NPM1[12080348;15144954;16376884]|NFYA[16959611]|NFYB[16959611;23734815]|HUWE1[15989956]|RPA1[15735006]|RANBP9[22653443]|RPA2[25609649]|MPP5[22653443]|APTX[15044383]|PPP1CA[15231748]|ITCH[16908849]|FOXA3[25609649]|MPHOSPH6[16169070]|OTUD5[19615732]|MAGEB18[16189514;16713569]|KDM1A[22653443;17805299]|UBE3A[16493710;12620801;26789255;29426014]|ETS2[26331536]|EP300[9194564;11907332;10518217;16782091;16611888;15542844;18485870;19339993;21471221;17906639;23010591;17438265;18391200;19217391;19234109;25651062;26302407]|RPGRIP1L[26638075]|ATAD3B[22653443]|ATAD3A[22653443]|HNRNPUL1[15907477;22653443]|FAM173A[16169070]|PPIF[22726440]|AIPL1[27173435;unassigned1312]|DDX5[20818423;15660129;24219989]|PSMD11[16169070]|RPS19BP1[17964266]|YTHDC2[22653443]|COX17[16169070]|STK4[25241761]|COP1[15103385;21625211]|UBB[17936559]|UBC[17139261;17170702;17159902;17268548;17290220;17568776;18309296;18388957;18566590;19098711;19619542;19536131;19798103]|HSPA9[17184779;20153329;22340593;22726440]|SMAD2[19345189;25241761;25670079]|UBE2I[15327968;18624398]|PDHA1[29128334]|HSPA5[17184779]|VDR[20227041]|EIF2S2[16169070]|CLK3[23602568]|NR4A1[17139261]|BMP1[18624398]|JMY[10518217]|BHLHE40[17347673;22723347]|MKRN1[19536131]|NABP1[25402006]|TCF4[25609649;25402006]|UBA1[29187402]|SAE1[15327968]|YWHAE[18812399]|GSK3B[14744935;21900206]|HSPB1[16169070;17184779;25241761]|HMGB1[9472015;23063560]|USP39[19615732]|YWHAQ[22653443]|ZIC3[25402006]|RB1CC1[21775823]|TOP1MT[25402006]|CASP1[11278253]|COLGALT1[22653443]|ZNF385A[17719541]|YWHAG[19933256;18812399;22653443]|GUSBP1[16169070]|TBP[7799929;9349482]|USP42[22085928]|TWNK[22653443]|AXIN1[21057547]|PPP2R5C[17245430;21460856;25241761]|SAFB[21130767]|YWHAZ[16376338;22653443]|CREB1[25241761]|OTUB1[22124327]|LAMA4[16169070;25241761]|USP11[19615732]|NT5C2[22653443]|AURKB[29340707]|HSPD1[22726440]|MAPK1[25241761]|DROSHA[24219989;19626115]|KDM4A[23871696]|NAP1L1[14966293]|S100B[20591429]|USP28[22653443]|USP29[21285945]|MAPK11[17254968]|NEURL4[22653443]|BAX[25241761]|" }, "interpro": { "all": [ [ "p53, tetramerisation domain", "P04637-7", "ENST00000504937" ], [ "p53, tetramerisation domain", "A0A087X1Q1", "ENST00000619186" ], [ "p53, tetramerisation domain", "P04637-4", "ENST00000610292" ], [ "p53, tetramerisation domain", "P04637", "ENST00000269305" ], [ "p53, tetramerisation domain", "P04637-4", "ENST00000620739" ], [ "p53, tetramerisation domain", "P04637", "ENST00000445888" ], [ "p53, tetramerisation domain", "P04637-4", "ENST00000619485" ] ], "domain": [ "p53, tetramerisation domain", "p53, tetramerisation domain", "p53, tetramerisation domain", "p53, tetramerisation domain", "p53, tetramerisation domain", "p53, tetramerisation domain", "p53, tetramerisation domain" ] }, "javierre_promoters": null, "linsight": null, "loftool": { "loftool_score": 0.000965 }, "lrt": { "lrt_converted_rankscore": 0.8433, "lrt_omega": 0, "lrt_pred": "Damaging", "lrt_score": 0 }, "metalr": { "bp4_benign": null, "pp3_pathogenic": "Moderate", "pred": "Damaging", 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The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). 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"all": [ [ "AAGAB", " genetic interference ", "23284306", " \"synthetic growth defect sensu biogrid \" ", "1278703" ], [ "AARS", " affinity chromatography technology ", "32807901", " physical association ", "2976333" ], [ "AASDH", " bioid ", "38580884", " physical association ", "3713332" ], [ "AATF", " affinity chromatography technology ", "25996291", " physical association ", "2596577" ], [ "ABCA12", " genetic interference ", "24378760", " \"synthetic lethality sensu biogrid \" ", "3477142" ], [ "ABCF1", " affinity chromatography technology ", "32807901", " physical association ", "2976331" ], [ "ABCF2", " affinity chromatography technology ", "32807901", " physical association ", "2976524" ], [ "ABHD16B", " genetic interference ", "30862715", " \"negative genetic interaction sensu biogrid \" ", "2872157" ], [ "ABL1", " affinity chromatography technology ", "17992189", " physical association ", "3731298" ], [ "ABR", " affinity chromatography technology ", "23443559", " physical association ", "954635" ], [ "ABR", " affinity chromatography technology ", "32807901", " physical association ", "2976577" ], [ "ACACA", " affinity chromatography technology ", "31152661", " physical association ", "2659065" ], [ "ACAD10", " affinity chromatography technology ", "32807901", " physical association ", "2976787" ], [ "ACADM", " affinity chromatography technology ", "32807901", " physical association ", "2976655" ], [ "ACBD3", " affinity chromatography technology ", "32807901", " physical association ", "2976206" ], [ "ACKR3", " two hybrid ", "27229929", " direct interaction ", "2380967" ], [ "ACLY", " affinity chromatography technology ", "32807901", " physical association ", "2976172" ], [ "ACO2", " affinity chromatography technology ", "35140242", " physical association ", "3321365" ], [ "ACSL4", " affinity chromatography technology ", "23443559", " physical association ", "954636" ], [ "ACTA2", " affinity chromatography technology ", "23443559", " physical association ", "954638" ], [ "ACTB", " affinity chromatography technology ", "23443559", " physical association ", "954641" ], [ "ACTB", " affinity chromatography technology ", "25144556", " physical association ", "1029304" ], [ "ACTB", " affinity chromatography technology ", "35474131", " physical association ", "3638467" ], [ "ACTBL2", " affinity chromatography technology ", "25144556", " physical association ", "1029305" ], [ "ACTG1", " affinity chromatography technology ", "32807901", " physical association ", "2976274" ], [ "ACTL6A", " affinity chromatography technology ", "17878219", " physical association ", "658087" ], [ "ACTN4", " affinity chromatography technology ", "32807901", " physical association ", "2976565" ], [ "ACVR1C", " genetic interference ", "23284306", " \"synthetic growth defect sensu biogrid \" ", "1278704" ], [ "ADAM28", " genetic interference ", "23284306", " \"synthetic growth defect sensu biogrid \" ", "1278705" ], [ "ADAM9", " affinity chromatography technology ", "32807901", " physical association ", "2976606" ], [ "ADAR", " affinity chromatography technology ", "32807901", " physical association ", "2976389" ], [ "ADCK5", " affinity chromatography technology ", "32807901", " physical association ", "2976176" ], [ "ADD1", " affinity chromatography technology ", "32807901", " physical association ", "2976610" ], [ "ADD3", " affinity chromatography technology ", "32807901", " physical association ", "2976217" ], [ "ADH5", " affinity chromatography technology ", "20308539", " physical association ", "438249" ], [ "ADNP", " affinity chromatography technology ", "32807901", " physical association ", "2976456" ], [ "ADNP", " bioid ", "34795231", " physical association ", "3338713" ], [ "ADO", " genetic interference ", "38580884", " \"synthetic rescue sensu biogrid \" ", "3712957" ], [ "AGBL2", " affinity chromatography technology ", "20308539", " physical association ", "438250" ], [ "AGGF1", " affinity chromatography technology ", "33069768", " physical association ", "3196702" ], [ "AGO1", " affinity chromatography technology ", "20308539", " physical association ", "438259" ], [ "AGO1", " affinity chromatography technology ", "32807901", " physical association ", "2976587" ], [ "AGO2", " affinity chromatography technology ", "20308539", " physical association ", "438260" ], [ "AGO2", " affinity chromatography technology ", "32807901", " physical association ", "2976574" ], [ "AGPAT6", " affinity chromatography technology ", "32807901", " physical association ", "2976649" ], [ "AGT", " two hybrid ", "22416758", " direct interaction ", "643047" ], [ "AGTPBP1", " affinity chromatography technology ", "32807901", " physical association ", "2976178" ], [ "AGTRAP", " affinity chromatography technology ", "32807901", " physical association ", "2976561" ], [ "AHCTF1", " affinity chromatography technology ", "32807901", " physical association ", "2976836" ], [ "AHCY", " affinity chromatography technology ", "34591612", " physical association ", "3496461" ], [ "AHCY", " affinity chromatography technology ", "37438558", " physical association ", "3739025" ], [ "AIFM1", " affinity chromatography technology ", "32807901", " physical association ", "2976346" ], [ "AIFM2", " affinity chromatography technology ", "23443559", " physical association ", "954647" ], [ "AIMP2", " affinity chromatography technology ", "18695251", " physical association ", "327648" ], [ "AIMP2", " pull down ", "18695251", " direct interaction ", "327649" ], [ "AIMP2", " two hybrid ", "18695251", " direct interaction ", "327650" ], [ "AIP", " bioid ", "38580884", " physical association ", "3713457" ], [ "AIPL1", " affinity chromatography technology ", "27173435", " physical association ", "2332108" ], [ "AKAP12", " affinity chromatography technology ", "23443559", " physical association ", "954648" ], [ "AKAP5", " two hybrid ", "31182485", " direct interaction ", "2878990" ], [ "AKAP8L", " affinity chromatography technology ", "32807901", " 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"METHYLBENZETHONIUM CHLORIDE", 0.02, "CHEMBL1321398", "" ], [ "KINASE", "", "(R)-INDOPROFEN", 0.15, "CHEMBL264931", "" ], [ "KINASE", "", "E-FLUPENTIXOL", 0.02, "CHEMBL42055", "" ], [ "KINASE", "", "7-METHOXYISOFLAVONE", 0.03, "CHEMBL563919", "" ], [ "KINASE", "", "GNF-PF-308", 0.05, "CHEMBL600334", "" ], [ "KINASE", "", "NSC-663284", 0.02, "CHEMBL337173", "" ], [ "KINASE", "", "BENZO(K)FLUORANTHENE", 0.01, "CHEMBL1441574", "" ], [ "KINASE", "", "EMBELIN", 0.01, "CHEMBL221137", "" ], [ "KINASE", "", "LGX818", 0.02, "CHEMBL3301612", "" ], [ "KINASE", "", "INOSITOL", 0.02, "CHEMBL1222251", 16733561 ], [ "KINASE", "", "GNF-PF-1184", 0.15, "CHEMBL600347", "" ], [ "KINASE", "", "PD-160170", 0.05, "CHEMBL422942", "" ], [ "KINASE", "", "KINETIN RIBOSIDE", 0.04, "CHEMBL411066", "" ], [ "KINASE", "", "CID 926663", 0.04, "CHEMBL265686", "" ], [ "KINASE", "", "MICHLER'S KETONE", 0.02, "CHEMBL15137", "" ], [ "KINASE", "", "A-77636", 0.03, "CHEMBL291143", "" ], [ "KINASE", "", "BITHIONOL", 0.01, 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"TEMOZOLOMIDE", 0.03, "CHEMBL810", 24248532 ], [ "KINASE", "", "FANCHININ", 0.03, "CHEMBL176045", "" ], [ "KINASE", "", "GNF-PF-3416", 0.05, "CHEMBL579550", "" ], [ "KINASE", "", "VX-970", 0.02, "CHEMBL3989870", "" ], [ "KINASE", "", "FURAZOLIDONE", 0.07, "CHEMBL1103", "" ], [ "KINASE", "", "GNF-PF-3012", 0.07, "CHEMBL582715", "" ], [ "KINASE", "", "GNF-PF-2968", 0.05, "CHEMBL582473", "" ], [ "KINASE", "", "QPI-1002", 0.15, "CHEMBL4297574", "" ], [ "KINASE", "", "AMOXAPINE", 0.01, "CHEMBL1113", "" ], [ "KINASE", "", "SJ000124275", 0.04, "CHEMBL602150", "" ], [ "KINASE", "", "PACLITAXEL", 0.01, "CHEMBL428647", 16459017 ], [ "KINASE", "", "CID 4101591", 0.01, "CHEMBL428789", "" ], [ "KINASE", "", "PANITUMUMAB", 0.01, "CHEMBL1201827", 28514312 ], [ "KINASE", "", "STREPTONIGRIN", 0.01, "CHEMBL11417", 12027749 ], [ "KINASE", "", "SELICICLIB", 0.05, "CHEMBL14762", "22862161,26826118" ], [ "KINASE", "", "OSM-S-85", 0.07, "CHEMBL1494650", "" ], [ "KINASE", "", "PENTACHLOROPHENOL", 0.01, "CHEMBL75967", "" ], [ "KINASE", "", "SANGUINARINE SULFATE", 0.01, "CHEMBL1565133", "" ], [ "KINASE", "", "CLEMASTINE", 0.02, "CHEMBL1626", "" ], [ "KINASE", "", "ZIRAM", 0.01, "CHEMBL1519327", "" ], [ "KINASE", "", "CID 739615", 0.02, "CHEMBL260560", "" ] ], "category": "KINASE", "chembl": "CHEMBL3186011", "interaction": null, "name": "APR-246", "pmid": "22965953,21239882,21415220,26086967,27179933", "score": 1.04 }, "encode_tfbs": null, "ensembl_regulatory_build": null, "esm1b": { "all": [ [ "ENST00000504937", -9.102, 0.71033, "Deleterious", "", "" ], [ "ENST00000610292", -9.454, 0.71033, "Deleterious", "", "" ], [ "ENST00000269305", -9.528, 0.71033, "Deleterious", "", "" ], [ "ENST00000620739", -9.454, 0.71033, "Deleterious", "", "" ], [ "ENST00000445888", -9.528, 0.71033, "Deleterious", "", "" ], [ "ENST00000619485", -9.454, 0.71033, "Deleterious", "", "" ] ], "bp4_benign": null, "pp3_pathogenic": null, "prediction": "Deleterious", "rankscore": 0.71033, "score": -9.528, "transcript": "ENST00000445888;ENST00000269305" }, "ess_gene": { "ess_gene": "E", "ess_gene_crispr": "N", "ess_gene_crispr2": "S", "ess_gene_gene_trap": "N", "indispensability_pred": "E", "indispensability_score": "1" }, "fathmm": null, "fathmm_mkl": { "bp4_pathogenic": null, "fathmm_mkl_coding_pred": "Damaging", "fathmm_mkl_coding_rankscore": 0.9467399999999999, "fathmm_mkl_coding_score": 0.99336, "fathmm_mkl_group": "AEFBI", "pp3_pathogenic": "Supporting" }, "fathmm_xf_coding": { "bp4_pathogenic": null, "fathmm_xf_coding_pred": "Damaging", "fathmm_xf_coding_rankscore": 0.7985300000000001, "fathmm_xf_coding_score": 0.8752270000000001, "pp3_pathogenic": "Supporting" }, "fitcons": { "fitcons_coding_pred": 0, "fitcons_coding_rankscore": 0.73137, "fitcons_coding_score": 0.706548 }, "genehancer": null, "gerp": { "bp4_benign": null, "bp4_pathogenic": null, "gerp_nr": 5.43, "gerp_rs": 5.43, "gerp_rs_rank": 0.78925 }, "geuvadis": null, "ghis": { "ghis": 0.599240746 }, "gnomad": { "af": 0.00000399064592595, "af_afr": null, "af_amr": null, "af_asj": null, "af_eas": null, "af_fin": null, "af_nfe": 0.00000882861885087, "af_oth": null, "af_sas": null }, "gnomad3": { "af": 0.0000139614, "af_afr": 0, "af_asj": 0.000301023, "af_eas": 0, "af_fin": 0, "af_lat": 0, "af_nfe": 0.000015488, "af_oth": 0, "af_sas": 0 }, "go": { "bpo_id": "GO:0000122;GO:0002244;GO:0006289;GO:0006355;GO:0006357;GO:0006914;GO:0006915;GO:0006974;GO:0006979;GO:0006983;GO:0007265;GO:0007623;GO:0008104;GO:0008285;GO:0008340;GO:0009299;GO:0009410;GO:0009411;GO:0010212;GO:0010332;GO:0010628;GO:0012501;GO:0016032;GO:0030308;GO:0030330;GO:0031571;GO:0032211;GO:0033209;GO:0034644;GO:0042149;GO:0042771;GO:0042981;GO:0043065;GO:0043066;GO:0043153;GO:0045815;GO:0045892;GO:0045893;GO:0045899;GO:0045944;GO:0046677;GO:0048147;GO:0048511;GO:0048512;GO:0048539;GO:0051053;GO:0051097;GO:0051262;GO:0051726;GO:0060218;GO:0060333;GO:0062100;GO:0065003;GO:0070059;GO:0070245;GO:0071456;GO:0071466;GO:0071479;GO:0071480;GO:0072331;GO:0072332;GO:0072717;GO:0090200;GO:0090398;GO:0090399;GO:0090403;GO:0097190;GO:0097193;GO:0097252;GO:1900119;GO:1902749;GO:1902895;GO:1903451;GO:1905856;GO:2000379;GO:2000774;GO:2001242;GO:2001244", "bpo_name": "negative regulation of transcription by RNA polymerase II;hematopoietic progenitor cell differentiation;nucleotide-excision repair;regulation of DNA-templated transcription;regulation of transcription by RNA polymerase II;autophagy;apoptotic process;DNA damage response;response to oxidative stress;ER overload response;Ras protein signal transduction;circadian rhythm;intracellular protein localization;negative regulation of cell population proliferation;determination of adult lifespan;mRNA transcription;response to xenobiotic stimulus;response to UV;response to ionizing radiation;response to gamma radiation;positive regulation of gene expression;programmed cell death;viral process;negative regulation of cell growth;DNA damage response, signal transduction by p53 class mediator;mitotic G1 DNA damage checkpoint signaling;negative regulation of telomere maintenance via telomerase;tumor necrosis factor-mediated signaling pathway;cellular response to UV;cellular response to glucose starvation;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;regulation of apoptotic process;positive regulation of apoptotic process;negative regulation of apoptotic process;entrainment of circadian clock by photoperiod;transcription initiation-coupled chromatin remodeling;negative regulation of DNA-templated transcription;positive regulation of DNA-templated transcription;positive regulation of RNA polymerase II transcription preinitiation complex assembly;positive regulation of transcription by RNA polymerase II;response to antibiotic;negative regulation of fibroblast proliferation;rhythmic process;circadian behavior;bone marrow development;negative regulation of DNA metabolic process;negative regulation of helicase activity;protein tetramerization;regulation of cell cycle;hematopoietic stem cell differentiation;type II interferon-mediated signaling pathway;positive regulation of programmed necrotic cell death;protein-containing complex assembly;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;positive regulation of thymocyte apoptotic process;cellular response to hypoxia;cellular response to xenobiotic stimulus;cellular response to ionizing radiation;cellular response to gamma radiation;signal transduction by p53 class mediator;intrinsic apoptotic signaling pathway by p53 class mediator;cellular response to actinomycin D;positive regulation of release of cytochrome c from mitochondria;cellular senescence;replicative senescence;oxidative stress-induced premature senescence;apoptotic signaling pathway;intrinsic apoptotic signaling pathway;oligodendrocyte apoptotic process;positive regulation of execution phase of apoptosis;regulation of cell cycle G2/M phase transition;positive regulation of miRNA transcription;negative regulation of G1 to G0 transition;negative regulation of pentose-phosphate shunt;positive regulation of reactive oxygen species metabolic process;positive regulation of cellular senescence;regulation of intrinsic apoptotic signaling pathway;positive regulation of intrinsic apoptotic signaling pathway", "cco_id": "GO:0000785;GO:0005634;GO:0005654;GO:0005667;GO:0005730;GO:0005737;GO:0005739;GO:0005759;GO:0005783;GO:0005813;GO:0005829;GO:0016363;GO:0016604;GO:0016605;GO:0017053;GO:0032991", "cco_name": "chromatin;nucleus;nucleoplasm;transcription regulator complex;nucleolus;cytoplasm;mitochondrion;mitochondrial matrix;endoplasmic reticulum;centrosome;cytosol;nuclear matrix;nuclear body;PML body;transcription repressor complex;protein-containing complex", "mfo_id": "GO:0000976;GO:0000978;GO:0000981;GO:0000987;GO:0001046;GO:0001094;GO:0001223;GO:0001227;GO:0001228;GO:0002020;GO:0002039;GO:0003677;GO:0003682;GO:0003700;GO:0003730;GO:0005507;GO:0005515;GO:0008270;GO:0019899;GO:0030971;GO:0031625;GO:0036310;GO:0042802;GO:0042826;GO:0046872;GO:0046982;GO:0051087;GO:0051721;GO:0061629;GO:0071889;GO:0097371;GO:0097718;GO:0140296;GO:0140677;GO:0140693;GO:1990841", "mfo_name": "transcription cis-regulatory region binding;RNA polymerase II cis-regulatory region sequence-specific DNA binding;DNA-binding transcription factor activity, RNA polymerase II-specific;cis-regulatory region sequence-specific DNA binding;core promoter sequence-specific DNA binding;TFIID-class transcription factor complex binding;transcription coactivator binding;DNA-binding transcription repressor activity, RNA polymerase II-specific;DNA-binding transcription activator activity, RNA polymerase II-specific;protease binding;p53 binding;DNA binding;chromatin binding;DNA-binding transcription factor activity;mRNA 3'-UTR binding;copper ion binding;protein binding;zinc ion binding;enzyme binding;receptor tyrosine kinase binding;ubiquitin protein ligase binding;ATP-dependent DNA/DNA annealing activity;identical protein binding;histone deacetylase binding;metal ion binding;protein heterodimerization activity;protein-folding chaperone binding;protein phosphatase 2A binding;RNA polymerase II-specific DNA-binding transcription factor binding;14-3-3 protein binding;MDM2/MDM4 family protein binding;disordered domain specific binding;general transcription initiation factor binding;molecular function activator activity;molecular condensate scaffold activity;promoter-specific chromatin binding" }, "grasp": null, "gtex": null, "gwas_catalog": null, "intact": { "acts": "AIMP2;AIPL1;ANK2;ANXA3;ANXA7;APOH;APPL1;APTX;AR;ARIH2;ARL3;ARRB1;ASH2L;ATAD3A;ATAD3B;ATF3;ATG7;ATM;ATR;AURKB;AXIN1;BAG1;BAG2;BAG6;BANP;BARD1;BAX;BCL2;BCL2L1;BCL6;BCR;BHLHE40;BLM;BMP1;BMX;BRCA1;BRCA2;BRD7;BTBD2;BTRC;CABLES1;CASP1;CCAR2;CCDC106;CCDC8;CCL18;CCT2;CCT3;CCT4;CCT5;CCT6A;CCT7;CCT8;CDC42;CDK2;CDKN1A;CDKN2A;CDKN2C;CEBPB;CEBPZ;CEP120;CEP128;CEP135;CEP152;CHEK1;CHEK2;CITED1;CLK3;COLGALT1;COP1;COPS4;COX17;CREB1;CREBBP;CRK;CSE1L;CSNK1D;CSNK1E;CSNK2A1;CSNK2A2;CSNK2B;CUL7;CUL9;CXXC1;DAXX;DDX17;DDX5;DKFZp434J046;DLEU1;DLST;DROSHA;DUSP26;DVL2;DYNC1I1;EAF2;EEF2;EGLN3;EGR1;EIF2S2;EP300;ERH;ETS2;FAM173A;FBXO11;FBXW8;FCAMR;FOXA3;FOXB1;FOXC1;FOXG1;FOXJ3;FOXK1;FOXK2;FOXN1;FOXO3;FOXP1;FOXQ1;FOXS1;FXYD6;GADD45A;GFI1;GLI1;GNL3;GNL3L;GPX2;GRB2;GSK3B;GSTM4;GTF2H1;GUSBP1;HDAC1;HDAC2;HDAC3;HDAC8;HERC2;HINFP;HIPK1;HIPK2;HIPK3;HMGB1;HNRNPK;HNRNPUL1;HSP90AA1;HSP90AB1;HSPA1A;HSPA1L;HSPA5;HSPA9;HSPB1;HSPD1;HTT;HUWE1;ICK;IFI16;IKBKB;ING2;ING4;IP6K2;ITCH;JMJD6;JMY;JUN;KAT2B;KAT5;KAT8;KDM1A;KDM4A;KHDRBS1;KIAA0087;KMT2A;KMT2C;KMT2E;KSR1;KSR2;LAMA4;LMNA;LRRK2;MAD2L1BP;MAEA;MAGEA2;MAGEB18;MAGEC2;MAP1B;MAPK1;MAPK11;MAPKAPK5;MDM2;MDM4;MED1;MEN1;MKRN1;MOV10;MPDZ;MPHOSPH6;MPP5;MRPS22;MT1A;MTOR;MYC;NABP1;NAP1L1;NCL;NCOA2;NCOA6;NCOR2;NEDD8;NEIL3;NEURL4;NFATC1;NFYA;NFYB;NIN;NINL;NMT1;NMT2;NOC2L;NOL3;NPAS3;NPM1;NR0B2;NR4A1;NRDC;NT5C2;NUAK1;NUDT16L1;NUMB;OBSL1;OFD1;OLA1;OTUB1;OTUD5;PADI1;PAFAH1B3;PAGR1;PARD3;PARP1;PAXIP1;PBK;PCDHA4;PDHA1;PES1;PHB;PHC3;PHF1;PIAS1;PIAS2;PIAS4;PIN1;PLCG2;PLK1;PLOD3;PML;PNP;POLRMT;PPA1;PPIF;PPM1G;PPP1CA;PPP1CC;PPP1R13B;PPP1R13L;PPP1R15A;PPP2R1A;PPP2R2A;PPP2R5C;PRKAB2;PRKCD;PSMC1;PSMD11;PSMD2;PSMD5;PSME3;PTBP3;PTK2;PYCR3;RAB4A;RABGAP1;RAD51;RANBP9;RAP1B;RASGRF1;RB1;RB1CC1;RBBP5;RBPJ;RBX1;RCC1;RCHY1;RFWD3;RING1;RNASEL;RNF20;RNF40;RPA1;RPA2;RPGRIP1L;RPL5;RPS19BP1;RPS27A;RPS3;RPS7;RRM2B;RYBP;S100A1;S100A2;S100A4;S100A6;S100A8;S100B;SAE1;SAFB;SAFB2;SARS2;SAT1;SCAMP1;SERPINB9;SETD1A;SETD7;SFN;SIN3A;SIRT1;SKP1;SMAD2;SMARCA4;SMARCA5;SMARCAL1;SMARCC1;SMG5;SMG7;SMN1;SMYD2;SNAI1;SNRPN;SOX4;SP1;SPICE1;SREBF1;SREBF2;SRPK1;SSX2IP;STK11;STK4;STUB1;STX5;SULT1E1;SUMO1;SUMO2;SYVN1;TBP;TCF4;TCP1;TDRD12;THAP8;TK1;TMSB4X;TOE1;TOP1MT;TOP3A;TOPORS;TP53;TP53BP1;TP53BP2;TP53TG1;TP63;TPT1;TRAF1;TRIM24;TRIM28;TSPAN10;TSPYL4;TUBB;TUBB2A;TUBB2C;TUBB3;TWIST1;TWIST2;TWNK;UBA1;UBB;UBC;UBE2E1;UBE2I;UBE3A;UFD1;UHRF2;USP11;USP28;USP29;USP39;USP42;USP7;VDR;VRK1;WDR33;WDR48;WDR5;WDR82;WRN;WWOX;XPO1;XRCC1;XRCC6;YTHDC2;YWHAE;YWHAG;YWHAQ;YWHAZ;YY1;YY2;ZCCHC10;ZIC3;ZNF24;ZNF385A;ZNF420", "intact": "RB1[20871633]|RPL5[22653443]|NOC2L[16322561]|RBPJ[26302407]|PSMD5[22653443]|MYC[21150319]|PSMD2[22653443]|DLEU1[16169070]|DDX17[15660129]|MED1[15848166]|DAXX[16845383;14557665;15364927;25241761;21134643]|PRKAB2[27107012]|CSNK2A1[22975381;25241761]|CSNK2A2[22653443]|PRKCD[16377624]|SCAMP1[16713569]|BCR[16169070;25241761]|FCAMR[21988832]|AR[19481544]|WDR82[23870121]|PSME3[18309296]|MAP1B[18656471]|PARD3[22653443]|ATF3[16169070]|TSPYL4[22653443]|PADI1[25402006]|ZNF24[16169070]|PLCG2[25814554]|PCDHA4[16169070]|SFN[20206173;21625211]|ATG7[22499945]|GSTM4[16169070]|BARD1[15782130]|TOE1[19508870]|CREBBP[10823891;9194564;10196247;25314079;19234109;19805293]|JUN[25609649]|PLK1[16753148;19833129;22653443]|SETD1A[23870121]|MAD2L1BP[16169070]|NFATC1[25609649]|NR0B2[22575647]|PHC3[27705803]|MOV10[25609649]|HNRNPK[21821029;23092970]|NMT1[16530191]|SNAI1[20385133]|NMT2[16530191]|FXYD6[16169070]|CDKN1A[16616141;21900206;25241761]|WDR48[19615732]|PHF1[27705803]|SETD7[15525938;21988832;16415881;17108971;17805299;21245319]|ASH2L[23870121;19433796]|SMG7[22653443]|GLI1[25609649]|SMG5[22653443;25609649]|ING4[15251430]|IKBKB[19883646;19196987]|ING2[16782091]|TMSB4X[16169070]|PBK[17482142;20622899]|ANXA7[21900206]|TK1[16169070;21900206]|NINL[26638075]|APPL1[25814554]|OFD1[26638075]|RING1[29187402]|ANXA3[16169070]|SERPINB9[16169070]|NUDT16L1[22653443]|SIRT1[11672523;17964266;12006491;15205477;18235501;18235502;21245319]|GNL3[12464630]|WDR33[16169070]|NCOR2[24449765]|KAT2B[16959611]|TUBB2C[22653443]|TUBB2A[22653443]|TCP1[22653443]|PAFAH1B3[16169070]|RNASEL[25609649]|HTT[10823891]|KIAA0087[16169070]|DLST[29128334]|WRN[11427532;15735006]|FOXS1[25609649]|SULT1E1[16169070]|TP53TG1[16169070]|RPS3[19656744]|STX5[16169070]|CCL18[16169070]|BRD7[20228809;20660729]|RPS27A[22653443]|WWOX[15580310]|EGLN3[26972000]|CDKN2C[16169070]|HSPA1L[17184779;25241761]|CDKN2A[12740913;22653443]|SYVN1[17170702]|GTF2H1[18354501]|HIPK1[12702766]|HIPK3[23602568]|HIPK2[15896780;16212962;21057547]|HINFP[21516116]|RYBP[19098711]|CCDC8[22653443]|PSMC1[22653443]|RFWD3[20173098]|HSPA1A[25241761]|CSE1L[17719542]|CEP120[26638075]|PLOD3[22653443]|SAT1[16169070]|CEP128[26638075]|FOXQ1[25609649]|YY1[25402006]|PPP1CC[17274640]|STK11[21317932]|MAEA[22653443]|YY2[25402006]|TUBB3[22653443]|MEN1[15960975]|PIAS4[11388671]|USP7[11923872;16845383;17268548;21170034;22653443;15916963;16402859;16474402;22056774]|SNRPN[16169070]|CEP135[26638075]|RPS7[17310983]|S100A2[20591429]|FBXW8[22653443;25609649]|S100A1[20591429]|SPICE1[26638075]|UBE2E1[29187402]|VRK1[15542844;24492002;29340707]|POLRMT[25609649]|FBXO11[17098746]|PIAS2[18624398;25241761]|RNF40[19410543]|PIAS1[15133049;25241761]|RBX1[22653443]|FOXP1[25609649]|NCL[22103682]|S100A6[20591429]|ERH[16169070]|MAPKAPK5[17254968]|S100A4[19740107;20591429;23752197]|S100A8[16169070]|CUL9[18230339;22653443;25609649]|KMT2E[21423215]|KHDRBS1[22653443]|CUL7[17298945;22653443;25609649]|BLM[22653443]|KMT2A[15960975]|ARL3[16169070]|KMT2C[19433796]|PHB[16319068;20134482;24380853]|FOXO3[14976264;25241761]|NPAS3[25609649]|RAP1B[21900206]|BAG6[22653443]|BAG2[22653443;25036637]|BTBD2[16169070]|BAG1[25036637]|DVL2[16189514;16713569;27107012]|SAFB2[21130767]|SMYD2[25609649;17805299;21782458]|SMN1[21900206]|MPDZ[22653443]|ZNF420[20713054]|IP6K2[21078964]|RAB4A[16169070]|NRDC[22653443]|BMX[16186805]|EEF2[22653443]|FOXN1[25609649]|COPS4[22653443]|GNL3L[21132010]|BCL6[25402006]|SP1[15710382;21831840]|CDK2[25241761]|MDM2[14704432;8875929;15848166;15144954;16212962;12915590;16845383;11178989;17139261;17159902;17268548;17347673;17310983;17875722;18309296;10196247;18485870;19166840;19098711;19411066;20591429;20708156;21170087;21132010;21988832;21726810;22085928;22575647;22659184;22819825;22510990;22975381;22653443;25241761;23776060;19656744;25609649;16432196;17080083;17438265;17470788;18172499;18316739;19234109;19255450;20173098;21857681;24207125;24667498;29997244]|BCL2[19521340;12667443]|TDRD12[22653443]|PIN1[12397362;21741598;21900206;17906639]|MDM4[15604276;17875722;19521340;20515689;20705607;15916963;25609649;17080083;19255450;24667498]|BCL2L1[16151013;21900206;12667443;14963330;24814347]|PPP1R13B[21513714]|HSP90AB1[22939624]|LRRK2[24725412]|RASGRF1[16753148]|ARRB1[21857681]|TSPAN10[22653443]|PAGR1[19039327]|SUMO1[16732283;19684601;20534433]|SIN3A[10823891;11359905]|PPP1R13L[21513714;17906639;23623661;18275817]|SUMO2[20534433]|WDR5[15960975;23870121;19433796]|GPX2[21988832]|HSP90AA1[21460846]|KSR1[27086506]|TRAF1[22653443]|KSR2[27086506]|DUSP26[20562916]|PTBP3[22575643]|SARS2[22653443]|RRM2B[19015526]|NUMB[18172499]|CRK[25814554]|SSX2IP[26638075]|PPP1R15A[29109149]|CEBPB[16227626]|HDAC2[17805299]|HDAC3[16847267]|UHRF2[21952639]|HDAC1[16959611;20075864;25241761]|CXXC1[23870121]|FOXK2[25609649]|FOXK1[25609649]|RCHY1[17568776;20452352;21988832;19043414]|HDAC8[17721440]|PPM1G[22653443]|CDC42[16169070]|IFI16[11146555;21397192]|RBBP5[15960975;23870121;19433796]|RNF20[19410543]|CEP152[26638075]|FOXJ3[25609649]|CABLES1[11706030]|PML[12915590;21057547;12006491;25241761]|MTOR[19619545]|NIN[26638075]|RAD51[9380510]|CEBPZ[12534345]|STUB1[25036637]|TPT1[21081126;22451927]|SMARCAL1[22653443]|GFI1[23410974]|PPP2R2A[17245430]|CCAR2[18235501]|PNP[16169070]|HERC2[22653443]|KAT5[18485870]|TRIM28[20864041]|PPP2R1A[17245430;25241761]|CHEK2[10724175;15862297;18833288]|CHEK1[16511572]|TRIM24[19556538]|KAT8[16601686;15960975]|RCC1[21900206]|MAGEA2[20864041;16847267]|BTRC[19196987]|TP63[19345189;21741598]|SOX4[19234109]|SKP1[22653443]|SMARCC1[18303029]|ANK2[20195357]|CSNK1D[25241761]|CSNK1E[25241761]|JMJD6[24667498]|NEIL3[25402006]|MT1A[16442532]|THAP8[16169070]|PPA1[16169070]|CSNK2B[22653443]|TP53[16291740;17612295;19339993;21988832;21522129;22653443;14985081;25609649;25402006;16461914;17620598;18087040;19667193;20004160;20159469;20364130;21178074;22972749]|OBSL1[22653443;25609649]|PAXIP1[19433796]|FOXG1[25609649]|TWIST2[22975381]|TWIST1[18504427;22975381;25402006]|NUAK1[21317932]|APOH[18624398]|TP53BP2[8875926;21513714;14985081;18275817]|TP53BP1[11877378;22653443;14985081;17805299;19433796;25579814;25651062;25837623]|MAGEC2[20864041]|BANP[20075864]|EGR1[14744935]|XRCC6[15782130]|GADD45A[21900206]|SMARCA5[25609649]|EAF2[27107012]|XRCC1[15044383]|PYCR3[22653443]|PTK2[15855171;19857493;25241761]|SMARCA4[18303029]|SRPK1[21130767]|ICK[23602568]|CCT6A[22653443]|AIMP2[18695251]|ATM[10864201]|GRB2[22653443]|ATR[16293623]|ZCCHC10[16169070]|CITED1[20227041]|OLA1[22653443]|BRCA1[9926942]|BRCA2[20421506]|XPO1[17268548;18952844]|ARIH2[16169070;22819825]|UFD1[21900206]|CCT3[22653443]|NCOA2[20195357]|SREBF1[22265415]|CCT2[22653443]|PARP1[12898523;14627987;15044383]|NCOA6[19433796]|TUBB[22653443]|MRPS22[22653443]|TOP3A[22653443]|TOPORS[17290218]|SREBF2[22265415]|FOXC1[25609649]|RABGAP1[22653443]|DKFZp434J046[22653443]|NEDD8[22653443]|CCDC106[16169070;20159018]|NOL3[18087040]|PES1[25609649]|LMNA[29568061]|CCT8[22653443]|CCT7[22653443]|CCT5[16169070;22653443]|DYNC1I1[16616141]|CCT4[22653443]|FOXB1[25609649]|NPM1[12080348;15144954;16376884]|NFYA[16959611]|NFYB[16959611;23734815]|HUWE1[15989956]|RPA1[15735006]|RANBP9[22653443]|RPA2[25609649]|MPP5[22653443]|APTX[15044383]|PPP1CA[15231748]|ITCH[16908849]|FOXA3[25609649]|MPHOSPH6[16169070]|OTUD5[19615732]|MAGEB18[16189514;16713569]|KDM1A[22653443;17805299]|UBE3A[16493710;12620801;26789255;29426014]|ETS2[26331536]|EP300[9194564;11907332;10518217;16782091;16611888;15542844;18485870;19339993;21471221;17906639;23010591;17438265;18391200;19217391;19234109;25651062;26302407]|RPGRIP1L[26638075]|ATAD3B[22653443]|ATAD3A[22653443]|HNRNPUL1[15907477;22653443]|FAM173A[16169070]|PPIF[22726440]|AIPL1[27173435;unassigned1312]|DDX5[20818423;15660129;24219989]|PSMD11[16169070]|RPS19BP1[17964266]|YTHDC2[22653443]|COX17[16169070]|STK4[25241761]|COP1[15103385;21625211]|UBB[17936559]|UBC[17139261;17170702;17159902;17268548;17290220;17568776;18309296;18388957;18566590;19098711;19619542;19536131;19798103]|HSPA9[17184779;20153329;22340593;22726440]|SMAD2[19345189;25241761;25670079]|UBE2I[15327968;18624398]|PDHA1[29128334]|HSPA5[17184779]|VDR[20227041]|EIF2S2[16169070]|CLK3[23602568]|NR4A1[17139261]|BMP1[18624398]|JMY[10518217]|BHLHE40[17347673;22723347]|MKRN1[19536131]|NABP1[25402006]|TCF4[25609649;25402006]|UBA1[29187402]|SAE1[15327968]|YWHAE[18812399]|GSK3B[14744935;21900206]|HSPB1[16169070;17184779;25241761]|HMGB1[9472015;23063560]|USP39[19615732]|YWHAQ[22653443]|ZIC3[25402006]|RB1CC1[21775823]|TOP1MT[25402006]|CASP1[11278253]|COLGALT1[22653443]|ZNF385A[17719541]|YWHAG[19933256;18812399;22653443]|GUSBP1[16169070]|TBP[7799929;9349482]|USP42[22085928]|TWNK[22653443]|AXIN1[21057547]|PPP2R5C[17245430;21460856;25241761]|SAFB[21130767]|YWHAZ[16376338;22653443]|CREB1[25241761]|OTUB1[22124327]|LAMA4[16169070;25241761]|USP11[19615732]|NT5C2[22653443]|AURKB[29340707]|HSPD1[22726440]|MAPK1[25241761]|DROSHA[24219989;19626115]|KDM4A[23871696]|NAP1L1[14966293]|S100B[20591429]|USP28[22653443]|USP29[21285945]|MAPK11[17254968]|NEURL4[22653443]|BAX[25241761]|" }, "interpro": { "all": [ [ "p53, tetramerisation domain", "P04637-7", "ENST00000504937" ], [ "p53, tetramerisation domain", "A0A087X1Q1", "ENST00000619186" ], [ "p53, tetramerisation domain", "P04637-4", "ENST00000610292" ], [ "p53, tetramerisation domain", "P04637", "ENST00000269305" ], [ "p53, tetramerisation domain", "P04637-4", "ENST00000620739" ], [ "p53, tetramerisation domain", "P04637", "ENST00000445888" ], [ "p53, tetramerisation domain", "P04637-4", "ENST00000619485" ] ], "domain": [ "p53, tetramerisation domain", "p53, tetramerisation domain", "p53, tetramerisation domain", "p53, tetramerisation domain", "p53, tetramerisation domain", "p53, tetramerisation domain", "p53, tetramerisation domain" ] }, "javierre_promoters": null, "linsight": null, "loftool": { "loftool_score": 0.000965 }, "lrt": { "lrt_converted_rankscore": 0.8433, "lrt_omega": 0, "lrt_pred": "Damaging", "lrt_score": 0 }, "metalr": { "bp4_benign": null, "pp3_pathogenic": "Moderate", "pred": "Damaging", 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The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). 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"all": [ [ "AAGAB", " genetic interference ", "23284306", " \"synthetic growth defect sensu biogrid \" ", "1278703" ], [ "AARS", " affinity chromatography technology ", "32807901", " physical association ", "2976333" ], [ "AASDH", " bioid ", "38580884", " physical association ", "3713332" ], [ "AATF", " affinity chromatography technology ", "25996291", " physical association ", "2596577" ], [ "ABCA12", " genetic interference ", "24378760", " \"synthetic lethality sensu biogrid \" ", "3477142" ], [ "ABCF1", " affinity chromatography technology ", "32807901", " physical association ", "2976331" ], [ "ABCF2", " affinity chromatography technology ", "32807901", " physical association ", "2976524" ], [ "ABHD16B", " genetic interference ", "30862715", " \"negative genetic interaction sensu biogrid \" ", "2872157" ], [ "ABL1", " affinity chromatography technology ", "17992189", " physical association ", "3731298" ], [ "ABR", " affinity chromatography technology ", "23443559", " physical association ", "954635" ], [ "ABR", " affinity chromatography technology ", "32807901", " physical association ", "2976577" ], [ "ACACA", " affinity chromatography technology ", "31152661", " physical association ", "2659065" ], [ "ACAD10", " affinity chromatography technology ", "32807901", " physical association ", "2976787" ], [ "ACADM", " affinity chromatography technology ", "32807901", " physical association ", "2976655" ], [ "ACBD3", " affinity chromatography technology ", "32807901", " physical association ", "2976206" ], [ "ACKR3", " two hybrid ", "27229929", " direct interaction ", "2380967" ], [ "ACLY", " affinity chromatography technology ", "32807901", " physical association ", "2976172" ], [ "ACO2", " affinity chromatography technology ", "35140242", " physical association ", "3321365" ], [ "ACSL4", " affinity chromatography technology ", "23443559", " physical association ", "954636" ], [ "ACTA2", " affinity chromatography technology ", "23443559", " physical association ", "954638" ], [ "ACTB", " affinity chromatography technology ", "23443559", " physical association ", "954641" ], [ "ACTB", " affinity chromatography technology ", "25144556", " physical association ", "1029304" ], [ "ACTB", " affinity chromatography technology ", "35474131", " physical association ", "3638467" ], [ "ACTBL2", " affinity chromatography technology ", "25144556", " physical association ", "1029305" ], [ "ACTG1", " affinity chromatography technology ", "32807901", " physical association ", "2976274" ], [ "ACTL6A", " affinity chromatography technology ", "17878219", " physical association ", "658087" ], [ "ACTN4", " affinity chromatography technology ", "32807901", " physical association ", "2976565" ], [ "ACVR1C", " genetic interference ", "23284306", " \"synthetic growth defect sensu biogrid \" ", "1278704" ], [ "ADAM28", " genetic interference ", "23284306", " \"synthetic growth defect sensu biogrid \" ", "1278705" ], [ "ADAM9", " affinity chromatography technology ", "32807901", " physical association ", "2976606" ], [ "ADAR", " affinity chromatography technology ", "32807901", " physical association ", "2976389" ], [ "ADCK5", " affinity chromatography technology ", "32807901", " physical association ", "2976176" ], [ "ADD1", " affinity chromatography technology ", "32807901", " physical association ", "2976610" ], [ "ADD3", " affinity chromatography technology ", "32807901", " physical association ", "2976217" ], [ "ADH5", " affinity chromatography technology ", "20308539", " physical association ", "438249" ], [ "ADNP", " affinity chromatography technology ", "32807901", " physical association ", "2976456" ], [ "ADNP", " bioid ", "34795231", " physical association ", "3338713" ], [ "ADO", " genetic interference ", "38580884", " \"synthetic rescue sensu biogrid \" ", "3712957" ], [ "AGBL2", " affinity chromatography technology ", "20308539", " physical association ", "438250" ], [ "AGGF1", " affinity chromatography technology ", "33069768", " physical association ", "3196702" ], [ "AGO1", " affinity chromatography technology ", "20308539", " physical association ", "438259" ], [ "AGO1", " affinity chromatography technology ", "32807901", " physical association ", "2976587" ], [ "AGO2", " affinity chromatography technology ", "20308539", " physical association ", "438260" ], [ "AGO2", " affinity chromatography technology ", "32807901", " physical association ", "2976574" ], [ "AGPAT6", " affinity chromatography technology ", "32807901", " physical association ", "2976649" ], [ "AGT", " two hybrid ", "22416758", " direct interaction ", "643047" ], [ "AGTPBP1", " affinity chromatography technology ", "32807901", " physical association ", "2976178" ], [ "AGTRAP", " affinity chromatography technology ", "32807901", " physical association ", "2976561" ], [ "AHCTF1", " affinity chromatography technology ", "32807901", " physical association ", "2976836" ], [ "AHCY", " affinity chromatography technology ", "34591612", " physical association ", "3496461" ], [ "AHCY", " affinity chromatography technology ", "37438558", " physical association ", "3739025" ], [ "AIFM1", " affinity chromatography technology ", "32807901", " physical association ", "2976346" ], [ "AIFM2", " affinity chromatography technology ", "23443559", " physical association ", "954647" ], [ "AIMP2", " affinity chromatography technology ", "18695251", " physical association ", "327648" ], [ "AIMP2", " pull down ", "18695251", " direct interaction ", "327649" ], [ "AIMP2", " two hybrid ", "18695251", " direct interaction ", "327650" ], [ "AIP", " bioid ", "38580884", " physical association ", "3713457" ], [ "AIPL1", " affinity chromatography technology ", "27173435", " physical association ", "2332108" ], [ "AKAP12", " affinity chromatography technology ", "23443559", " physical association ", "954648" ], [ "AKAP5", " two hybrid ", "31182485", " direct interaction ", "2878990" ], [ "AKAP8L", " affinity chromatography technology ", "32807901", " 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], [ "KINASE", "", "CID 926663", 0.04, "CHEMBL265686", "" ], [ "KINASE", "", "MICHLER'S KETONE", 0.02, "CHEMBL15137", "" ], [ "KINASE", "", "A-77636", 0.03, "CHEMBL291143", "" ], [ "KINASE", "", "BITHIONOL", 0.01, "CHEMBL290106", "" ], [ "KINASE", "", "PHENANTHROLINE", 0.01, "CHEMBL415879", "" ], [ "KINASE", "", "OLVANIL", 0.02, "CHEMBL76903", "" ], [ "KINASE", "", "TPCK", 0.01, "CHEMBL60718", "" ], [ "KINASE", "", "7,8,3'-TRIHYDROXYFLAVONE", 0.02, "CHEMBL225513", "" ], [ "KINASE", "", "FUROXAN", 0.03, "CHEMBL336467", "" ], [ "KINASE", "", "CLOFOCTOL", 0.02, "CHEMBL1476605", "" ], [ "KINASE", "", "TERPYRIDINE", 0.02, "CHEMBL89445", "" ], [ "KINASE", "", "TCMDC-125575", 0.03, "CHEMBL587620", "" ], [ "KINASE", "", "TRIACETYLRESVERATROL", 0.07, "CHEMBL597744", "" ], [ "KINASE", "", "CID 94381", 0.01, "CHEMBL374632", "" ], [ "KINASE", "", "GNF-PF-1549", 0.04, "CHEMBL227959", "" ], [ "KINASE", "", "ABT-263", 0.03, "CHEMBL443684", 27659046 ], [ "KINASE", "", "PACLITAXEL", 0.01, "CHEMBL428647", 24065105 ], [ "KINASE", "", "PROPACHLOR", 0.02, "CHEMBL1394829", "" ], [ "KINASE", "", "IODOQUINOL", 0.02, "CHEMBL86754", "" ], [ "KINASE", "", "CHLORANIL", 0.01, "CHEMBL192627", "" ], [ "KINASE", "", "TEMOZOLOMIDE", 0.03, "CHEMBL810", 24248532 ], [ "KINASE", "", "FANCHININ", 0.03, "CHEMBL176045", "" ], [ "KINASE", "", "GNF-PF-3416", 0.05, "CHEMBL579550", "" ], [ "KINASE", "", "VX-970", 0.02, "CHEMBL3989870", "" ], [ "KINASE", "", "FURAZOLIDONE", 0.07, "CHEMBL1103", "" ], [ "KINASE", "", "GNF-PF-3012", 0.07, "CHEMBL582715", "" ], [ "KINASE", "", "GNF-PF-2968", 0.05, "CHEMBL582473", "" ], [ "KINASE", "", "QPI-1002", 0.15, "CHEMBL4297574", "" ], [ "KINASE", "", "AMOXAPINE", 0.01, "CHEMBL1113", "" ], [ "KINASE", "", "SJ000124275", 0.04, "CHEMBL602150", "" ], [ "KINASE", "", "PACLITAXEL", 0.01, "CHEMBL428647", 16459017 ], [ "KINASE", "", "CID 4101591", 0.01, "CHEMBL428789", "" ], [ "KINASE", "", "PANITUMUMAB", 0.01, "CHEMBL1201827", 28514312 ], [ "KINASE", "", "STREPTONIGRIN", 0.01, "CHEMBL11417", 12027749 ], [ "KINASE", "", "SELICICLIB", 0.05, "CHEMBL14762", "22862161,26826118" ], [ "KINASE", "", "OSM-S-85", 0.07, "CHEMBL1494650", "" ], [ "KINASE", "", "PENTACHLOROPHENOL", 0.01, "CHEMBL75967", "" ], [ "KINASE", "", "SANGUINARINE SULFATE", 0.01, "CHEMBL1565133", "" ], [ "KINASE", "", "CLEMASTINE", 0.02, "CHEMBL1626", "" ], [ "KINASE", "", "ZIRAM", 0.01, "CHEMBL1519327", "" ], [ "KINASE", "", "CID 739615", 0.02, "CHEMBL260560", "" ] ], "category": "KINASE", "chembl": "CHEMBL3186011", "interaction": null, "name": "APR-246", "pmid": "22965953,21239882,21415220,26086967,27179933", "score": 1.04 }, "encode_tfbs": null, "ensembl_regulatory_build": null, "esm1b": null, "ess_gene": { "ess_gene": "E", "ess_gene_crispr": "N", "ess_gene_crispr2": "S", "ess_gene_gene_trap": "N", "indispensability_pred": "E", "indispensability_score": "1" }, "fathmm": null, "fathmm_mkl": null, "fathmm_xf_coding": null, "fitcons": null, "genehancer": null, "gerp": null, "geuvadis": null, "ghis": { "ghis": 0.599240746 }, "gnomad": null, "gnomad3": null, "go": { "bpo_id": "GO:0000122;GO:0002244;GO:0006289;GO:0006355;GO:0006357;GO:0006914;GO:0006915;GO:0006974;GO:0006979;GO:0006983;GO:0007265;GO:0007623;GO:0008104;GO:0008285;GO:0008340;GO:0009299;GO:0009410;GO:0009411;GO:0010212;GO:0010332;GO:0010628;GO:0012501;GO:0016032;GO:0030308;GO:0030330;GO:0031571;GO:0032211;GO:0033209;GO:0034644;GO:0042149;GO:0042771;GO:0042981;GO:0043065;GO:0043066;GO:0043153;GO:0045815;GO:0045892;GO:0045893;GO:0045899;GO:0045944;GO:0046677;GO:0048147;GO:0048511;GO:0048512;GO:0048539;GO:0051053;GO:0051097;GO:0051262;GO:0051726;GO:0060218;GO:0060333;GO:0062100;GO:0065003;GO:0070059;GO:0070245;GO:0071456;GO:0071466;GO:0071479;GO:0071480;GO:0072331;GO:0072332;GO:0072717;GO:0090200;GO:0090398;GO:0090399;GO:0090403;GO:0097190;GO:0097193;GO:0097252;GO:1900119;GO:1902749;GO:1902895;GO:1903451;GO:1905856;GO:2000379;GO:2000774;GO:2001242;GO:2001244", "bpo_name": "negative regulation of transcription by RNA polymerase II;hematopoietic progenitor cell differentiation;nucleotide-excision repair;regulation of DNA-templated transcription;regulation of transcription by RNA polymerase II;autophagy;apoptotic process;DNA damage response;response to oxidative stress;ER overload response;Ras protein signal transduction;circadian rhythm;intracellular protein localization;negative regulation of cell population proliferation;determination of adult lifespan;mRNA transcription;response to xenobiotic stimulus;response to UV;response to ionizing radiation;response to gamma radiation;positive regulation of gene expression;programmed cell death;viral process;negative regulation of cell growth;DNA damage response, signal transduction by p53 class mediator;mitotic G1 DNA damage checkpoint signaling;negative regulation of telomere maintenance via telomerase;tumor necrosis factor-mediated signaling pathway;cellular response to UV;cellular response to glucose starvation;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;regulation of apoptotic process;positive regulation of apoptotic process;negative regulation of apoptotic process;entrainment of circadian clock by photoperiod;transcription initiation-coupled chromatin remodeling;negative regulation of DNA-templated transcription;positive regulation of DNA-templated transcription;positive regulation of RNA polymerase II transcription preinitiation complex assembly;positive regulation of transcription by RNA polymerase II;response to antibiotic;negative regulation of fibroblast proliferation;rhythmic process;circadian behavior;bone marrow development;negative regulation of DNA metabolic process;negative regulation of helicase activity;protein tetramerization;regulation of cell cycle;hematopoietic stem cell differentiation;type II interferon-mediated signaling pathway;positive regulation of programmed necrotic cell death;protein-containing complex assembly;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;positive regulation of thymocyte apoptotic process;cellular response to hypoxia;cellular response to xenobiotic stimulus;cellular response to ionizing radiation;cellular response to gamma radiation;signal transduction by p53 class mediator;intrinsic apoptotic signaling pathway by p53 class mediator;cellular response to actinomycin D;positive regulation of release of cytochrome c from mitochondria;cellular senescence;replicative senescence;oxidative stress-induced premature senescence;apoptotic signaling pathway;intrinsic apoptotic signaling pathway;oligodendrocyte apoptotic process;positive regulation of execution phase of apoptosis;regulation of cell cycle G2/M phase transition;positive regulation of miRNA transcription;negative regulation of G1 to G0 transition;negative regulation of pentose-phosphate shunt;positive regulation of reactive oxygen species metabolic process;positive regulation of cellular senescence;regulation of intrinsic apoptotic signaling pathway;positive regulation of intrinsic apoptotic signaling pathway", "cco_id": "GO:0000785;GO:0005634;GO:0005654;GO:0005667;GO:0005730;GO:0005737;GO:0005739;GO:0005759;GO:0005783;GO:0005813;GO:0005829;GO:0016363;GO:0016604;GO:0016605;GO:0017053;GO:0032991", "cco_name": "chromatin;nucleus;nucleoplasm;transcription regulator complex;nucleolus;cytoplasm;mitochondrion;mitochondrial matrix;endoplasmic reticulum;centrosome;cytosol;nuclear matrix;nuclear body;PML body;transcription repressor complex;protein-containing complex", "mfo_id": "GO:0000976;GO:0000978;GO:0000981;GO:0000987;GO:0001046;GO:0001094;GO:0001223;GO:0001227;GO:0001228;GO:0002020;GO:0002039;GO:0003677;GO:0003682;GO:0003700;GO:0003730;GO:0005507;GO:0005515;GO:0008270;GO:0019899;GO:0030971;GO:0031625;GO:0036310;GO:0042802;GO:0042826;GO:0046872;GO:0046982;GO:0051087;GO:0051721;GO:0061629;GO:0071889;GO:0097371;GO:0097718;GO:0140296;GO:0140677;GO:0140693;GO:1990841", "mfo_name": "transcription cis-regulatory region binding;RNA polymerase II cis-regulatory region sequence-specific DNA binding;DNA-binding transcription factor activity, RNA polymerase II-specific;cis-regulatory region sequence-specific DNA binding;core promoter sequence-specific DNA binding;TFIID-class transcription factor complex binding;transcription coactivator binding;DNA-binding transcription repressor activity, RNA polymerase II-specific;DNA-binding transcription activator activity, RNA polymerase II-specific;protease binding;p53 binding;DNA binding;chromatin binding;DNA-binding transcription factor activity;mRNA 3'-UTR binding;copper ion binding;protein binding;zinc ion binding;enzyme binding;receptor tyrosine kinase binding;ubiquitin protein ligase binding;ATP-dependent DNA/DNA annealing activity;identical protein binding;histone deacetylase binding;metal ion binding;protein heterodimerization activity;protein-folding chaperone binding;protein phosphatase 2A binding;RNA polymerase II-specific DNA-binding transcription factor binding;14-3-3 protein binding;MDM2/MDM4 family protein binding;disordered domain specific binding;general transcription initiation factor binding;molecular function activator activity;molecular condensate scaffold activity;promoter-specific chromatin binding" }, "grasp": null, "gtex": null, "gwas_catalog": null, "intact": { "acts": "AIMP2;AIPL1;ANK2;ANXA3;ANXA7;APOH;APPL1;APTX;AR;ARIH2;ARL3;ARRB1;ASH2L;ATAD3A;ATAD3B;ATF3;ATG7;ATM;ATR;AURKB;AXIN1;BAG1;BAG2;BAG6;BANP;BARD1;BAX;BCL2;BCL2L1;BCL6;BCR;BHLHE40;BLM;BMP1;BMX;BRCA1;BRCA2;BRD7;BTBD2;BTRC;CABLES1;CASP1;CCAR2;CCDC106;CCDC8;CCL18;CCT2;CCT3;CCT4;CCT5;CCT6A;CCT7;CCT8;CDC42;CDK2;CDKN1A;CDKN2A;CDKN2C;CEBPB;CEBPZ;CEP120;CEP128;CEP135;CEP152;CHEK1;CHEK2;CITED1;CLK3;COLGALT1;COP1;COPS4;COX17;CREB1;CREBBP;CRK;CSE1L;CSNK1D;CSNK1E;CSNK2A1;CSNK2A2;CSNK2B;CUL7;CUL9;CXXC1;DAXX;DDX17;DDX5;DKFZp434J046;DLEU1;DLST;DROSHA;DUSP26;DVL2;DYNC1I1;EAF2;EEF2;EGLN3;EGR1;EIF2S2;EP300;ERH;ETS2;FAM173A;FBXO11;FBXW8;FCAMR;FOXA3;FOXB1;FOXC1;FOXG1;FOXJ3;FOXK1;FOXK2;FOXN1;FOXO3;FOXP1;FOXQ1;FOXS1;FXYD6;GADD45A;GFI1;GLI1;GNL3;GNL3L;GPX2;GRB2;GSK3B;GSTM4;GTF2H1;GUSBP1;HDAC1;HDAC2;HDAC3;HDAC8;HERC2;HINFP;HIPK1;HIPK2;HIPK3;HMGB1;HNRNPK;HNRNPUL1;HSP90AA1;HSP90AB1;HSPA1A;HSPA1L;HSPA5;HSPA9;HSPB1;HSPD1;HTT;HUWE1;ICK;IFI16;IKBKB;ING2;ING4;IP6K2;ITCH;JMJD6;JMY;JUN;KAT2B;KAT5;KAT8;KDM1A;KDM4A;KHDRBS1;KIAA0087;KMT2A;KMT2C;KMT2E;KSR1;KSR2;LAMA4;LMNA;LRRK2;MAD2L1BP;MAEA;MAGEA2;MAGEB18;MAGEC2;MAP1B;MAPK1;MAPK11;MAPKAPK5;MDM2;MDM4;MED1;MEN1;MKRN1;MOV10;MPDZ;MPHOSPH6;MPP5;MRPS22;MT1A;MTOR;MYC;NABP1;NAP1L1;NCL;NCOA2;NCOA6;NCOR2;NEDD8;NEIL3;NEURL4;NFATC1;NFYA;NFYB;NIN;NINL;NMT1;NMT2;NOC2L;NOL3;NPAS3;NPM1;NR0B2;NR4A1;NRDC;NT5C2;NUAK1;NUDT16L1;NUMB;OBSL1;OFD1;OLA1;OTUB1;OTUD5;PADI1;PAFAH1B3;PAGR1;PARD3;PARP1;PAXIP1;PBK;PCDHA4;PDHA1;PES1;PHB;PHC3;PHF1;PIAS1;PIAS2;PIAS4;PIN1;PLCG2;PLK1;PLOD3;PML;PNP;POLRMT;PPA1;PPIF;PPM1G;PPP1CA;PPP1CC;PPP1R13B;PPP1R13L;PPP1R15A;PPP2R1A;PPP2R2A;PPP2R5C;PRKAB2;PRKCD;PSMC1;PSMD11;PSMD2;PSMD5;PSME3;PTBP3;PTK2;PYCR3;RAB4A;RABGAP1;RAD51;RANBP9;RAP1B;RASGRF1;RB1;RB1CC1;RBBP5;RBPJ;RBX1;RCC1;RCHY1;RFWD3;RING1;RNASEL;RNF20;RNF40;RPA1;RPA2;RPGRIP1L;RPL5;RPS19BP1;RPS27A;RPS3;RPS7;RRM2B;RYBP;S100A1;S100A2;S100A4;S100A6;S100A8;S100B;SAE1;SAFB;SAFB2;SARS2;SAT1;SCAMP1;SERPINB9;SETD1A;SETD7;SFN;SIN3A;SIRT1;SKP1;SMAD2;SMARCA4;SMARCA5;SMARCAL1;SMARCC1;SMG5;SMG7;SMN1;SMYD2;SNAI1;SNRPN;SOX4;SP1;SPICE1;SREBF1;SREBF2;SRPK1;SSX2IP;STK11;STK4;STUB1;STX5;SULT1E1;SUMO1;SUMO2;SYVN1;TBP;TCF4;TCP1;TDRD12;THAP8;TK1;TMSB4X;TOE1;TOP1MT;TOP3A;TOPORS;TP53;TP53BP1;TP53BP2;TP53TG1;TP63;TPT1;TRAF1;TRIM24;TRIM28;TSPAN10;TSPYL4;TUBB;TUBB2A;TUBB2C;TUBB3;TWIST1;TWIST2;TWNK;UBA1;UBB;UBC;UBE2E1;UBE2I;UBE3A;UFD1;UHRF2;USP11;USP28;USP29;USP39;USP42;USP7;VDR;VRK1;WDR33;WDR48;WDR5;WDR82;WRN;WWOX;XPO1;XRCC1;XRCC6;YTHDC2;YWHAE;YWHAG;YWHAQ;YWHAZ;YY1;YY2;ZCCHC10;ZIC3;ZNF24;ZNF385A;ZNF420", "intact": "RB1[20871633]|RPL5[22653443]|NOC2L[16322561]|RBPJ[26302407]|PSMD5[22653443]|MYC[21150319]|PSMD2[22653443]|DLEU1[16169070]|DDX17[15660129]|MED1[15848166]|DAXX[16845383;14557665;15364927;25241761;21134643]|PRKAB2[27107012]|CSNK2A1[22975381;25241761]|CSNK2A2[22653443]|PRKCD[16377624]|SCAMP1[16713569]|BCR[16169070;25241761]|FCAMR[21988832]|AR[19481544]|WDR82[23870121]|PSME3[18309296]|MAP1B[18656471]|PARD3[22653443]|ATF3[16169070]|TSPYL4[22653443]|PADI1[25402006]|ZNF24[16169070]|PLCG2[25814554]|PCDHA4[16169070]|SFN[20206173;21625211]|ATG7[22499945]|GSTM4[16169070]|BARD1[15782130]|TOE1[19508870]|CREBBP[10823891;9194564;10196247;25314079;19234109;19805293]|JUN[25609649]|PLK1[16753148;19833129;22653443]|SETD1A[23870121]|MAD2L1BP[16169070]|NFATC1[25609649]|NR0B2[22575647]|PHC3[27705803]|MOV10[25609649]|HNRNPK[21821029;23092970]|NMT1[16530191]|SNAI1[20385133]|NMT2[16530191]|FXYD6[16169070]|CDKN1A[16616141;21900206;25241761]|WDR48[19615732]|PHF1[27705803]|SETD7[15525938;21988832;16415881;17108971;17805299;21245319]|ASH2L[23870121;19433796]|SMG7[22653443]|GLI1[25609649]|SMG5[22653443;25609649]|ING4[15251430]|IKBKB[19883646;19196987]|ING2[16782091]|TMSB4X[16169070]|PBK[17482142;20622899]|ANXA7[21900206]|TK1[16169070;21900206]|NINL[26638075]|APPL1[25814554]|OFD1[26638075]|RING1[29187402]|ANXA3[16169070]|SERPINB9[16169070]|NUDT16L1[22653443]|SIRT1[11672523;17964266;12006491;15205477;18235501;18235502;21245319]|GNL3[12464630]|WDR33[16169070]|NCOR2[24449765]|KAT2B[16959611]|TUBB2C[22653443]|TUBB2A[22653443]|TCP1[22653443]|PAFAH1B3[16169070]|RNASEL[25609649]|HTT[10823891]|KIAA0087[16169070]|DLST[29128334]|WRN[11427532;15735006]|FOXS1[25609649]|SULT1E1[16169070]|TP53TG1[16169070]|RPS3[19656744]|STX5[16169070]|CCL18[16169070]|BRD7[20228809;20660729]|RPS27A[22653443]|WWOX[15580310]|EGLN3[26972000]|CDKN2C[16169070]|HSPA1L[17184779;25241761]|CDKN2A[12740913;22653443]|SYVN1[17170702]|GTF2H1[18354501]|HIPK1[12702766]|HIPK3[23602568]|HIPK2[15896780;16212962;21057547]|HINFP[21516116]|RYBP[19098711]|CCDC8[22653443]|PSMC1[22653443]|RFWD3[20173098]|HSPA1A[25241761]|CSE1L[17719542]|CEP120[26638075]|PLOD3[22653443]|SAT1[16169070]|CEP128[26638075]|FOXQ1[25609649]|YY1[25402006]|PPP1CC[17274640]|STK11[21317932]|MAEA[22653443]|YY2[25402006]|TUBB3[22653443]|MEN1[15960975]|PIAS4[11388671]|USP7[11923872;16845383;17268548;21170034;22653443;15916963;16402859;16474402;22056774]|SNRPN[16169070]|CEP135[26638075]|RPS7[17310983]|S100A2[20591429]|FBXW8[22653443;25609649]|S100A1[20591429]|SPICE1[26638075]|UBE2E1[29187402]|VRK1[15542844;24492002;29340707]|POLRMT[25609649]|FBXO11[17098746]|PIAS2[18624398;25241761]|RNF40[19410543]|PIAS1[15133049;25241761]|RBX1[22653443]|FOXP1[25609649]|NCL[22103682]|S100A6[20591429]|ERH[16169070]|MAPKAPK5[17254968]|S100A4[19740107;20591429;23752197]|S100A8[16169070]|CUL9[18230339;22653443;25609649]|KMT2E[21423215]|KHDRBS1[22653443]|CUL7[17298945;22653443;25609649]|BLM[22653443]|KMT2A[15960975]|ARL3[16169070]|KMT2C[19433796]|PHB[16319068;20134482;24380853]|FOXO3[14976264;25241761]|NPAS3[25609649]|RAP1B[21900206]|BAG6[22653443]|BAG2[22653443;25036637]|BTBD2[16169070]|BAG1[25036637]|DVL2[16189514;16713569;27107012]|SAFB2[21130767]|SMYD2[25609649;17805299;21782458]|SMN1[21900206]|MPDZ[22653443]|ZNF420[20713054]|IP6K2[21078964]|RAB4A[16169070]|NRDC[22653443]|BMX[16186805]|EEF2[22653443]|FOXN1[25609649]|COPS4[22653443]|GNL3L[21132010]|BCL6[25402006]|SP1[15710382;21831840]|CDK2[25241761]|MDM2[14704432;8875929;15848166;15144954;16212962;12915590;16845383;11178989;17139261;17159902;17268548;17347673;17310983;17875722;18309296;10196247;18485870;19166840;19098711;19411066;20591429;20708156;21170087;21132010;21988832;21726810;22085928;22575647;22659184;22819825;22510990;22975381;22653443;25241761;23776060;19656744;25609649;16432196;17080083;17438265;17470788;18172499;18316739;19234109;19255450;20173098;21857681;24207125;24667498;29997244]|BCL2[19521340;12667443]|TDRD12[22653443]|PIN1[12397362;21741598;21900206;17906639]|MDM4[15604276;17875722;19521340;20515689;20705607;15916963;25609649;17080083;19255450;24667498]|BCL2L1[16151013;21900206;12667443;14963330;24814347]|PPP1R13B[21513714]|HSP90AB1[22939624]|LRRK2[24725412]|RASGRF1[16753148]|ARRB1[21857681]|TSPAN10[22653443]|PAGR1[19039327]|SUMO1[16732283;19684601;20534433]|SIN3A[10823891;11359905]|PPP1R13L[21513714;17906639;23623661;18275817]|SUMO2[20534433]|WDR5[15960975;23870121;19433796]|GPX2[21988832]|HSP90AA1[21460846]|KSR1[27086506]|TRAF1[22653443]|KSR2[27086506]|DUSP26[20562916]|PTBP3[22575643]|SARS2[22653443]|RRM2B[19015526]|NUMB[18172499]|CRK[25814554]|SSX2IP[26638075]|PPP1R15A[29109149]|CEBPB[16227626]|HDAC2[17805299]|HDAC3[16847267]|UHRF2[21952639]|HDAC1[16959611;20075864;25241761]|CXXC1[23870121]|FOXK2[25609649]|FOXK1[25609649]|RCHY1[17568776;20452352;21988832;19043414]|HDAC8[17721440]|PPM1G[22653443]|CDC42[16169070]|IFI16[11146555;21397192]|RBBP5[15960975;23870121;19433796]|RNF20[19410543]|CEP152[26638075]|FOXJ3[25609649]|CABLES1[11706030]|PML[12915590;21057547;12006491;25241761]|MTOR[19619545]|NIN[26638075]|RAD51[9380510]|CEBPZ[12534345]|STUB1[25036637]|TPT1[21081126;22451927]|SMARCAL1[22653443]|GFI1[23410974]|PPP2R2A[17245430]|CCAR2[18235501]|PNP[16169070]|HERC2[22653443]|KAT5[18485870]|TRIM28[20864041]|PPP2R1A[17245430;25241761]|CHEK2[10724175;15862297;18833288]|CHEK1[16511572]|TRIM24[19556538]|KAT8[16601686;15960975]|RCC1[21900206]|MAGEA2[20864041;16847267]|BTRC[19196987]|TP63[19345189;21741598]|SOX4[19234109]|SKP1[22653443]|SMARCC1[18303029]|ANK2[20195357]|CSNK1D[25241761]|CSNK1E[25241761]|JMJD6[24667498]|NEIL3[25402006]|MT1A[16442532]|THAP8[16169070]|PPA1[16169070]|CSNK2B[22653443]|TP53[16291740;17612295;19339993;21988832;21522129;22653443;14985081;25609649;25402006;16461914;17620598;18087040;19667193;20004160;20159469;20364130;21178074;22972749]|OBSL1[22653443;25609649]|PAXIP1[19433796]|FOXG1[25609649]|TWIST2[22975381]|TWIST1[18504427;22975381;25402006]|NUAK1[21317932]|APOH[18624398]|TP53BP2[8875926;21513714;14985081;18275817]|TP53BP1[11877378;22653443;14985081;17805299;19433796;25579814;25651062;25837623]|MAGEC2[20864041]|BANP[20075864]|EGR1[14744935]|XRCC6[15782130]|GADD45A[21900206]|SMARCA5[25609649]|EAF2[27107012]|XRCC1[15044383]|PYCR3[22653443]|PTK2[15855171;19857493;25241761]|SMARCA4[18303029]|SRPK1[21130767]|ICK[23602568]|CCT6A[22653443]|AIMP2[18695251]|ATM[10864201]|GRB2[22653443]|ATR[16293623]|ZCCHC10[16169070]|CITED1[20227041]|OLA1[22653443]|BRCA1[9926942]|BRCA2[20421506]|XPO1[17268548;18952844]|ARIH2[16169070;22819825]|UFD1[21900206]|CCT3[22653443]|NCOA2[20195357]|SREBF1[22265415]|CCT2[22653443]|PARP1[12898523;14627987;15044383]|NCOA6[19433796]|TUBB[22653443]|MRPS22[22653443]|TOP3A[22653443]|TOPORS[17290218]|SREBF2[22265415]|FOXC1[25609649]|RABGAP1[22653443]|DKFZp434J046[22653443]|NEDD8[22653443]|CCDC106[16169070;20159018]|NOL3[18087040]|PES1[25609649]|LMNA[29568061]|CCT8[22653443]|CCT7[22653443]|CCT5[16169070;22653443]|DYNC1I1[16616141]|CCT4[22653443]|FOXB1[25609649]|NPM1[12080348;15144954;16376884]|NFYA[16959611]|NFYB[16959611;23734815]|HUWE1[15989956]|RPA1[15735006]|RANBP9[22653443]|RPA2[25609649]|MPP5[22653443]|APTX[15044383]|PPP1CA[15231748]|ITCH[16908849]|FOXA3[25609649]|MPHOSPH6[16169070]|OTUD5[19615732]|MAGEB18[16189514;16713569]|KDM1A[22653443;17805299]|UBE3A[16493710;12620801;26789255;29426014]|ETS2[26331536]|EP300[9194564;11907332;10518217;16782091;16611888;15542844;18485870;19339993;21471221;17906639;23010591;17438265;18391200;19217391;19234109;25651062;26302407]|RPGRIP1L[26638075]|ATAD3B[22653443]|ATAD3A[22653443]|HNRNPUL1[15907477;22653443]|FAM173A[16169070]|PPIF[22726440]|AIPL1[27173435;unassigned1312]|DDX5[20818423;15660129;24219989]|PSMD11[16169070]|RPS19BP1[17964266]|YTHDC2[22653443]|COX17[16169070]|STK4[25241761]|COP1[15103385;21625211]|UBB[17936559]|UBC[17139261;17170702;17159902;17268548;17290220;17568776;18309296;18388957;18566590;19098711;19619542;19536131;19798103]|HSPA9[17184779;20153329;22340593;22726440]|SMAD2[19345189;25241761;25670079]|UBE2I[15327968;18624398]|PDHA1[29128334]|HSPA5[17184779]|VDR[20227041]|EIF2S2[16169070]|CLK3[23602568]|NR4A1[17139261]|BMP1[18624398]|JMY[10518217]|BHLHE40[17347673;22723347]|MKRN1[19536131]|NABP1[25402006]|TCF4[25609649;25402006]|UBA1[29187402]|SAE1[15327968]|YWHAE[18812399]|GSK3B[14744935;21900206]|HSPB1[16169070;17184779;25241761]|HMGB1[9472015;23063560]|USP39[19615732]|YWHAQ[22653443]|ZIC3[25402006]|RB1CC1[21775823]|TOP1MT[25402006]|CASP1[11278253]|COLGALT1[22653443]|ZNF385A[17719541]|YWHAG[19933256;18812399;22653443]|GUSBP1[16169070]|TBP[7799929;9349482]|USP42[22085928]|TWNK[22653443]|AXIN1[21057547]|PPP2R5C[17245430;21460856;25241761]|SAFB[21130767]|YWHAZ[16376338;22653443]|CREB1[25241761]|OTUB1[22124327]|LAMA4[16169070;25241761]|USP11[19615732]|NT5C2[22653443]|AURKB[29340707]|HSPD1[22726440]|MAPK1[25241761]|DROSHA[24219989;19626115]|KDM4A[23871696]|NAP1L1[14966293]|S100B[20591429]|USP28[22653443]|USP29[21285945]|MAPK11[17254968]|NEURL4[22653443]|BAX[25241761]|" 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"am_pathogenicity": 0.5538, "bp4_benign": null, "pp3_pathogenic": null, "protein_variant": "R335C", "transcript_id": "ENST00000445888.6", "uniprot_id": "P04637" }, "arrvars": null, "bayesdel": { "bayesdel_addAF_pred": "Deleterious", "bayesdel_addAF_rankscore": 0.87024, "bayesdel_addAF_score": 0.357028, "bayesdel_noAF_pred": "Deleterious", "bayesdel_noAF_rankscore": 0.86855, "bayesdel_noAF_score": 0.275069, "bp4_benign": null, "pp3_pathogenic": "Moderate" }, "biogrid": { "acts": 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"all": [ [ "AAGAB", " genetic interference ", "23284306", " \"synthetic growth defect sensu biogrid \" ", "1278703" ], [ "AARS", " affinity chromatography technology ", "32807901", " physical association ", "2976333" ], [ "AASDH", " bioid ", "38580884", " physical association ", "3713332" ], [ "AATF", " affinity chromatography technology ", "25996291", " physical association ", "2596577" ], [ "ABCA12", " genetic interference ", "24378760", " \"synthetic lethality sensu biogrid \" ", "3477142" ], [ "ABCF1", " affinity chromatography technology ", "32807901", " physical association ", "2976331" ], [ "ABCF2", " affinity chromatography technology ", "32807901", " physical association ", "2976524" ], [ "ABHD16B", " genetic interference ", "30862715", " \"negative genetic interaction sensu biogrid \" ", "2872157" ], [ "ABL1", " affinity chromatography technology ", "17992189", " physical association ", "3731298" ], [ "ABR", " affinity chromatography technology ", "23443559", " physical association ", "954635" ], [ "ABR", " affinity chromatography technology ", "32807901", " physical association ", "2976577" ], [ "ACACA", " affinity chromatography technology ", "31152661", " physical association ", "2659065" ], [ "ACAD10", " affinity chromatography technology ", "32807901", " physical association ", "2976787" ], [ "ACADM", " affinity chromatography technology ", "32807901", " physical association ", "2976655" ], [ "ACBD3", " affinity chromatography technology ", "32807901", " physical association ", "2976206" ], [ "ACKR3", " two hybrid ", "27229929", " direct interaction ", "2380967" ], [ "ACLY", " affinity chromatography technology ", "32807901", " physical association ", "2976172" ], [ "ACO2", " affinity chromatography technology ", "35140242", " physical association ", "3321365" ], [ "ACSL4", " affinity chromatography technology ", "23443559", " physical association ", "954636" ], [ "ACTA2", " affinity chromatography technology ", "23443559", " physical association ", "954638" ], [ "ACTB", " affinity chromatography technology ", "23443559", " physical association ", "954641" ], [ "ACTB", " affinity chromatography technology ", "25144556", " physical association ", "1029304" ], [ "ACTB", " affinity chromatography technology ", "35474131", " physical association ", "3638467" ], [ "ACTBL2", " affinity chromatography technology ", "25144556", " physical association ", "1029305" ], [ "ACTG1", " affinity chromatography technology ", "32807901", " physical association ", "2976274" ], [ "ACTL6A", " affinity chromatography technology ", "17878219", " physical association ", "658087" ], [ "ACTN4", " affinity chromatography technology ", "32807901", " physical association ", "2976565" ], [ "ACVR1C", " genetic interference ", "23284306", " \"synthetic growth defect sensu biogrid \" ", "1278704" ], [ "ADAM28", " genetic interference ", "23284306", " \"synthetic growth defect sensu biogrid \" ", "1278705" ], [ "ADAM9", " affinity chromatography technology ", "32807901", " physical association ", "2976606" ], [ "ADAR", " affinity chromatography technology ", "32807901", " physical association ", "2976389" ], [ "ADCK5", " affinity chromatography technology ", "32807901", " physical association ", "2976176" ], [ "ADD1", " affinity chromatography technology ", "32807901", " physical association ", "2976610" ], [ "ADD3", " affinity chromatography technology ", "32807901", " physical association ", "2976217" ], [ "ADH5", " affinity chromatography technology ", "20308539", " physical association ", "438249" ], [ "ADNP", " affinity chromatography technology ", "32807901", " physical association ", "2976456" ], [ "ADNP", " bioid ", "34795231", " physical association ", "3338713" ], [ "ADO", " genetic interference ", "38580884", " \"synthetic rescue sensu biogrid \" ", "3712957" ], [ "AGBL2", " affinity chromatography technology ", "20308539", " physical association ", "438250" ], [ "AGGF1", " affinity chromatography technology ", "33069768", " physical association ", "3196702" ], [ "AGO1", " affinity chromatography technology ", "20308539", " physical association ", "438259" ], [ "AGO1", " affinity chromatography technology ", "32807901", " physical association ", "2976587" ], [ "AGO2", " affinity chromatography technology ", "20308539", " physical association ", "438260" ], [ "AGO2", " affinity chromatography technology ", "32807901", " physical association ", "2976574" ], [ "AGPAT6", " affinity chromatography technology ", "32807901", " physical association ", "2976649" ], [ "AGT", " two hybrid ", "22416758", " direct interaction ", "643047" ], [ "AGTPBP1", " affinity chromatography technology ", "32807901", " physical association ", "2976178" ], [ "AGTRAP", " affinity chromatography technology ", "32807901", " physical association ", "2976561" ], [ "AHCTF1", " affinity chromatography technology ", "32807901", " physical association ", "2976836" ], [ "AHCY", " affinity chromatography technology ", "34591612", " physical association ", "3496461" ], [ "AHCY", " affinity chromatography technology ", "37438558", " physical association ", "3739025" ], [ "AIFM1", " affinity chromatography technology ", "32807901", " physical association ", "2976346" ], [ "AIFM2", " affinity chromatography technology ", "23443559", " physical association ", "954647" ], [ "AIMP2", " affinity chromatography technology ", "18695251", " physical association ", "327648" ], [ "AIMP2", " pull down ", "18695251", " direct interaction ", "327649" ], [ "AIMP2", " two hybrid ", "18695251", " direct interaction ", "327650" ], [ "AIP", " bioid ", "38580884", " physical association ", "3713457" ], [ "AIPL1", " affinity chromatography technology ", "27173435", " physical association ", "2332108" ], [ "AKAP12", " affinity chromatography technology ", "23443559", " physical association ", "954648" ], [ "AKAP5", " two hybrid ", "31182485", " direct interaction ", "2878990" ], [ "AKAP8L", " affinity chromatography technology ", "32807901", " 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"CHEMBL221137", "" ], [ "KINASE", "", "LGX818", 0.02, "CHEMBL3301612", "" ], [ "KINASE", "", "INOSITOL", 0.02, "CHEMBL1222251", 16733561 ], [ "KINASE", "", "GNF-PF-1184", 0.15, "CHEMBL600347", "" ], [ "KINASE", "", "PD-160170", 0.05, "CHEMBL422942", "" ], [ "KINASE", "", "KINETIN RIBOSIDE", 0.04, "CHEMBL411066", "" ], [ "KINASE", "", "CID 926663", 0.04, "CHEMBL265686", "" ], [ "KINASE", "", "MICHLER'S KETONE", 0.02, "CHEMBL15137", "" ], [ "KINASE", "", "A-77636", 0.03, "CHEMBL291143", "" ], [ "KINASE", "", "BITHIONOL", 0.01, "CHEMBL290106", "" ], [ "KINASE", "", "PHENANTHROLINE", 0.01, "CHEMBL415879", "" ], [ "KINASE", "", "OLVANIL", 0.02, "CHEMBL76903", "" ], [ "KINASE", "", "TPCK", 0.01, "CHEMBL60718", "" ], [ "KINASE", "", "7,8,3'-TRIHYDROXYFLAVONE", 0.02, "CHEMBL225513", "" ], [ "KINASE", "", "FUROXAN", 0.03, "CHEMBL336467", "" ], [ "KINASE", "", "CLOFOCTOL", 0.02, "CHEMBL1476605", "" ], [ "KINASE", "", "TERPYRIDINE", 0.02, "CHEMBL89445", "" ], [ "KINASE", "", "TCMDC-125575", 0.03, "CHEMBL587620", "" ], [ "KINASE", "", "TRIACETYLRESVERATROL", 0.07, "CHEMBL597744", "" ], [ "KINASE", "", "CID 94381", 0.01, "CHEMBL374632", "" ], [ "KINASE", "", "GNF-PF-1549", 0.04, "CHEMBL227959", "" ], [ "KINASE", "", "ABT-263", 0.03, "CHEMBL443684", 27659046 ], [ "KINASE", "", "PACLITAXEL", 0.01, "CHEMBL428647", 24065105 ], [ "KINASE", "", "PROPACHLOR", 0.02, "CHEMBL1394829", "" ], [ "KINASE", "", "IODOQUINOL", 0.02, "CHEMBL86754", "" ], [ "KINASE", "", "CHLORANIL", 0.01, "CHEMBL192627", "" ], [ "KINASE", "", "TEMOZOLOMIDE", 0.03, "CHEMBL810", 24248532 ], [ "KINASE", "", "FANCHININ", 0.03, "CHEMBL176045", "" ], [ "KINASE", "", "GNF-PF-3416", 0.05, "CHEMBL579550", "" ], [ "KINASE", "", "VX-970", 0.02, "CHEMBL3989870", "" ], [ "KINASE", "", "FURAZOLIDONE", 0.07, "CHEMBL1103", "" ], [ "KINASE", "", "GNF-PF-3012", 0.07, "CHEMBL582715", "" ], [ "KINASE", "", "GNF-PF-2968", 0.05, "CHEMBL582473", "" ], [ "KINASE", "", "QPI-1002", 0.15, "CHEMBL4297574", "" ], [ "KINASE", "", "AMOXAPINE", 0.01, "CHEMBL1113", "" ], [ "KINASE", "", "SJ000124275", 0.04, "CHEMBL602150", "" ], [ "KINASE", "", "PACLITAXEL", 0.01, "CHEMBL428647", 16459017 ], [ "KINASE", "", "CID 4101591", 0.01, "CHEMBL428789", "" ], [ "KINASE", "", "PANITUMUMAB", 0.01, "CHEMBL1201827", 28514312 ], [ "KINASE", "", "STREPTONIGRIN", 0.01, "CHEMBL11417", 12027749 ], [ "KINASE", "", "SELICICLIB", 0.05, "CHEMBL14762", "22862161,26826118" ], [ "KINASE", "", "OSM-S-85", 0.07, "CHEMBL1494650", "" ], [ "KINASE", "", "PENTACHLOROPHENOL", 0.01, "CHEMBL75967", "" ], [ "KINASE", "", "SANGUINARINE SULFATE", 0.01, "CHEMBL1565133", "" ], [ "KINASE", "", "CLEMASTINE", 0.02, "CHEMBL1626", "" ], [ "KINASE", "", "ZIRAM", 0.01, "CHEMBL1519327", "" ], [ "KINASE", "", "CID 739615", 0.02, "CHEMBL260560", "" ] ], "category": "KINASE", "chembl": "CHEMBL3186011", "interaction": null, "name": "APR-246", "pmid": "22965953,21239882,21415220,26086967,27179933", "score": 1.04 }, "encode_tfbs": null, "ensembl_regulatory_build": null, "esm1b": { "all": [ [ "ENST00000504937", -8.656, 0.67691, "Deleterious", "", "" ], [ "ENST00000610292", -8.971, 0.67691, "Deleterious", "", "" ], [ "ENST00000269305", -8.999, 0.67691, "Deleterious", "", "" ], [ "ENST00000620739", -8.971, 0.67691, "Deleterious", "", "" ], [ "ENST00000445888", -8.999, 0.67691, "Deleterious", "", "" ], [ "ENST00000619485", -8.971, 0.67691, "Deleterious", "", "" ] ], "bp4_benign": null, "pp3_pathogenic": null, "prediction": "Deleterious", "rankscore": 0.67691, "score": -8.999, "transcript": "ENST00000445888;ENST00000269305" }, "ess_gene": { "ess_gene": "E", "ess_gene_crispr": "N", "ess_gene_crispr2": "S", "ess_gene_gene_trap": "N", "indispensability_pred": "E", "indispensability_score": "1" }, "fathmm": null, "fathmm_mkl": { "bp4_pathogenic": null, "fathmm_mkl_coding_pred": "Damaging", "fathmm_mkl_coding_rankscore": 0.67365, "fathmm_mkl_coding_score": 0.9606299999999999, "fathmm_mkl_group": "AEFBI", "pp3_pathogenic": null }, "fathmm_xf_coding": { "bp4_pathogenic": null, "fathmm_xf_coding_pred": "Damaging", "fathmm_xf_coding_rankscore": 0.6503, "fathmm_xf_coding_score": 0.6897340000000001, "pp3_pathogenic": null }, "fitcons": { "fitcons_coding_pred": 0, "fitcons_coding_rankscore": 0.73137, "fitcons_coding_score": 0.706548 }, "genehancer": null, "gerp": { "bp4_benign": null, "bp4_pathogenic": null, "gerp_nr": 5.43, "gerp_rs": 3.45, "gerp_rs_rank": 0.38441 }, "geuvadis": null, "ghis": { "ghis": 0.599240746 }, "gnomad": null, "gnomad3": null, "go": { "bpo_id": "GO:0000122;GO:0002244;GO:0006289;GO:0006355;GO:0006357;GO:0006914;GO:0006915;GO:0006974;GO:0006979;GO:0006983;GO:0007265;GO:0007623;GO:0008104;GO:0008285;GO:0008340;GO:0009299;GO:0009410;GO:0009411;GO:0010212;GO:0010332;GO:0010628;GO:0012501;GO:0016032;GO:0030308;GO:0030330;GO:0031571;GO:0032211;GO:0033209;GO:0034644;GO:0042149;GO:0042771;GO:0042981;GO:0043065;GO:0043066;GO:0043153;GO:0045815;GO:0045892;GO:0045893;GO:0045899;GO:0045944;GO:0046677;GO:0048147;GO:0048511;GO:0048512;GO:0048539;GO:0051053;GO:0051097;GO:0051262;GO:0051726;GO:0060218;GO:0060333;GO:0062100;GO:0065003;GO:0070059;GO:0070245;GO:0071456;GO:0071466;GO:0071479;GO:0071480;GO:0072331;GO:0072332;GO:0072717;GO:0090200;GO:0090398;GO:0090399;GO:0090403;GO:0097190;GO:0097193;GO:0097252;GO:1900119;GO:1902749;GO:1902895;GO:1903451;GO:1905856;GO:2000379;GO:2000774;GO:2001242;GO:2001244", "bpo_name": "negative regulation of transcription by RNA polymerase II;hematopoietic progenitor cell differentiation;nucleotide-excision repair;regulation of DNA-templated transcription;regulation of transcription by RNA polymerase II;autophagy;apoptotic process;DNA damage response;response to oxidative stress;ER overload response;Ras protein signal transduction;circadian rhythm;intracellular protein localization;negative regulation of cell population proliferation;determination of adult lifespan;mRNA transcription;response to xenobiotic stimulus;response to UV;response to ionizing radiation;response to gamma radiation;positive regulation of gene expression;programmed cell death;viral process;negative regulation of cell growth;DNA damage response, signal transduction by p53 class mediator;mitotic G1 DNA damage checkpoint signaling;negative regulation of telomere maintenance via telomerase;tumor necrosis factor-mediated signaling pathway;cellular response to UV;cellular response to glucose starvation;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;regulation of apoptotic process;positive regulation of apoptotic process;negative regulation of apoptotic process;entrainment of circadian clock by photoperiod;transcription initiation-coupled chromatin remodeling;negative regulation of DNA-templated transcription;positive regulation of DNA-templated transcription;positive regulation of RNA polymerase II transcription preinitiation complex assembly;positive regulation of transcription by RNA polymerase II;response to antibiotic;negative regulation of fibroblast proliferation;rhythmic process;circadian behavior;bone marrow development;negative regulation of DNA metabolic process;negative regulation of helicase activity;protein tetramerization;regulation of cell cycle;hematopoietic stem cell differentiation;type II interferon-mediated signaling pathway;positive regulation of programmed necrotic cell death;protein-containing complex assembly;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;positive regulation of thymocyte apoptotic process;cellular response to hypoxia;cellular response to xenobiotic stimulus;cellular response to ionizing radiation;cellular response to gamma radiation;signal transduction by p53 class mediator;intrinsic apoptotic signaling pathway by p53 class mediator;cellular response to actinomycin D;positive regulation of release of cytochrome c from mitochondria;cellular senescence;replicative senescence;oxidative stress-induced premature senescence;apoptotic signaling pathway;intrinsic apoptotic signaling pathway;oligodendrocyte apoptotic process;positive regulation of execution phase of apoptosis;regulation of cell cycle G2/M phase transition;positive regulation of miRNA transcription;negative regulation of G1 to G0 transition;negative regulation of pentose-phosphate shunt;positive regulation of reactive oxygen species metabolic process;positive regulation of cellular senescence;regulation of intrinsic apoptotic signaling pathway;positive regulation of intrinsic apoptotic signaling pathway", "cco_id": "GO:0000785;GO:0005634;GO:0005654;GO:0005667;GO:0005730;GO:0005737;GO:0005739;GO:0005759;GO:0005783;GO:0005813;GO:0005829;GO:0016363;GO:0016604;GO:0016605;GO:0017053;GO:0032991", "cco_name": "chromatin;nucleus;nucleoplasm;transcription regulator complex;nucleolus;cytoplasm;mitochondrion;mitochondrial matrix;endoplasmic reticulum;centrosome;cytosol;nuclear matrix;nuclear body;PML body;transcription repressor complex;protein-containing complex", "mfo_id": "GO:0000976;GO:0000978;GO:0000981;GO:0000987;GO:0001046;GO:0001094;GO:0001223;GO:0001227;GO:0001228;GO:0002020;GO:0002039;GO:0003677;GO:0003682;GO:0003700;GO:0003730;GO:0005507;GO:0005515;GO:0008270;GO:0019899;GO:0030971;GO:0031625;GO:0036310;GO:0042802;GO:0042826;GO:0046872;GO:0046982;GO:0051087;GO:0051721;GO:0061629;GO:0071889;GO:0097371;GO:0097718;GO:0140296;GO:0140677;GO:0140693;GO:1990841", "mfo_name": "transcription cis-regulatory region binding;RNA polymerase II cis-regulatory region sequence-specific DNA binding;DNA-binding transcription factor activity, RNA polymerase II-specific;cis-regulatory region sequence-specific DNA binding;core promoter sequence-specific DNA binding;TFIID-class transcription factor complex binding;transcription coactivator binding;DNA-binding transcription repressor activity, RNA polymerase II-specific;DNA-binding transcription activator activity, RNA polymerase II-specific;protease binding;p53 binding;DNA binding;chromatin binding;DNA-binding transcription factor activity;mRNA 3'-UTR binding;copper ion binding;protein binding;zinc ion binding;enzyme binding;receptor tyrosine kinase binding;ubiquitin protein ligase binding;ATP-dependent DNA/DNA annealing activity;identical protein binding;histone deacetylase binding;metal ion binding;protein heterodimerization activity;protein-folding chaperone binding;protein phosphatase 2A binding;RNA polymerase II-specific DNA-binding transcription factor binding;14-3-3 protein binding;MDM2/MDM4 family protein binding;disordered domain specific binding;general transcription initiation factor binding;molecular function activator activity;molecular condensate scaffold activity;promoter-specific chromatin binding" }, "grasp": null, "gtex": null, "gwas_catalog": null, "intact": { "acts": "AIMP2;AIPL1;ANK2;ANXA3;ANXA7;APOH;APPL1;APTX;AR;ARIH2;ARL3;ARRB1;ASH2L;ATAD3A;ATAD3B;ATF3;ATG7;ATM;ATR;AURKB;AXIN1;BAG1;BAG2;BAG6;BANP;BARD1;BAX;BCL2;BCL2L1;BCL6;BCR;BHLHE40;BLM;BMP1;BMX;BRCA1;BRCA2;BRD7;BTBD2;BTRC;CABLES1;CASP1;CCAR2;CCDC106;CCDC8;CCL18;CCT2;CCT3;CCT4;CCT5;CCT6A;CCT7;CCT8;CDC42;CDK2;CDKN1A;CDKN2A;CDKN2C;CEBPB;CEBPZ;CEP120;CEP128;CEP135;CEP152;CHEK1;CHEK2;CITED1;CLK3;COLGALT1;COP1;COPS4;COX17;CREB1;CREBBP;CRK;CSE1L;CSNK1D;CSNK1E;CSNK2A1;CSNK2A2;CSNK2B;CUL7;CUL9;CXXC1;DAXX;DDX17;DDX5;DKFZp434J046;DLEU1;DLST;DROSHA;DUSP26;DVL2;DYNC1I1;EAF2;EEF2;EGLN3;EGR1;EIF2S2;EP300;ERH;ETS2;FAM173A;FBXO11;FBXW8;FCAMR;FOXA3;FOXB1;FOXC1;FOXG1;FOXJ3;FOXK1;FOXK2;FOXN1;FOXO3;FOXP1;FOXQ1;FOXS1;FXYD6;GADD45A;GFI1;GLI1;GNL3;GNL3L;GPX2;GRB2;GSK3B;GSTM4;GTF2H1;GUSBP1;HDAC1;HDAC2;HDAC3;HDAC8;HERC2;HINFP;HIPK1;HIPK2;HIPK3;HMGB1;HNRNPK;HNRNPUL1;HSP90AA1;HSP90AB1;HSPA1A;HSPA1L;HSPA5;HSPA9;HSPB1;HSPD1;HTT;HUWE1;ICK;IFI16;IKBKB;ING2;ING4;IP6K2;ITCH;JMJD6;JMY;JUN;KAT2B;KAT5;KAT8;KDM1A;KDM4A;KHDRBS1;KIAA0087;KMT2A;KMT2C;KMT2E;KSR1;KSR2;LAMA4;LMNA;LRRK2;MAD2L1BP;MAEA;MAGEA2;MAGEB18;MAGEC2;MAP1B;MAPK1;MAPK11;MAPKAPK5;MDM2;MDM4;MED1;MEN1;MKRN1;MOV10;MPDZ;MPHOSPH6;MPP5;MRPS22;MT1A;MTOR;MYC;NABP1;NAP1L1;NCL;NCOA2;NCOA6;NCOR2;NEDD8;NEIL3;NEURL4;NFATC1;NFYA;NFYB;NIN;NINL;NMT1;NMT2;NOC2L;NOL3;NPAS3;NPM1;NR0B2;NR4A1;NRDC;NT5C2;NUAK1;NUDT16L1;NUMB;OBSL1;OFD1;OLA1;OTUB1;OTUD5;PADI1;PAFAH1B3;PAGR1;PARD3;PARP1;PAXIP1;PBK;PCDHA4;PDHA1;PES1;PHB;PHC3;PHF1;PIAS1;PIAS2;PIAS4;PIN1;PLCG2;PLK1;PLOD3;PML;PNP;POLRMT;PPA1;PPIF;PPM1G;PPP1CA;PPP1CC;PPP1R13B;PPP1R13L;PPP1R15A;PPP2R1A;PPP2R2A;PPP2R5C;PRKAB2;PRKCD;PSMC1;PSMD11;PSMD2;PSMD5;PSME3;PTBP3;PTK2;PYCR3;RAB4A;RABGAP1;RAD51;RANBP9;RAP1B;RASGRF1;RB1;RB1CC1;RBBP5;RBPJ;RBX1;RCC1;RCHY1;RFWD3;RING1;RNASEL;RNF20;RNF40;RPA1;RPA2;RPGRIP1L;RPL5;RPS19BP1;RPS27A;RPS3;RPS7;RRM2B;RYBP;S100A1;S100A2;S100A4;S100A6;S100A8;S100B;SAE1;SAFB;SAFB2;SARS2;SAT1;SCAMP1;SERPINB9;SETD1A;SETD7;SFN;SIN3A;SIRT1;SKP1;SMAD2;SMARCA4;SMARCA5;SMARCAL1;SMARCC1;SMG5;SMG7;SMN1;SMYD2;SNAI1;SNRPN;SOX4;SP1;SPICE1;SREBF1;SREBF2;SRPK1;SSX2IP;STK11;STK4;STUB1;STX5;SULT1E1;SUMO1;SUMO2;SYVN1;TBP;TCF4;TCP1;TDRD12;THAP8;TK1;TMSB4X;TOE1;TOP1MT;TOP3A;TOPORS;TP53;TP53BP1;TP53BP2;TP53TG1;TP63;TPT1;TRAF1;TRIM24;TRIM28;TSPAN10;TSPYL4;TUBB;TUBB2A;TUBB2C;TUBB3;TWIST1;TWIST2;TWNK;UBA1;UBB;UBC;UBE2E1;UBE2I;UBE3A;UFD1;UHRF2;USP11;USP28;USP29;USP39;USP42;USP7;VDR;VRK1;WDR33;WDR48;WDR5;WDR82;WRN;WWOX;XPO1;XRCC1;XRCC6;YTHDC2;YWHAE;YWHAG;YWHAQ;YWHAZ;YY1;YY2;ZCCHC10;ZIC3;ZNF24;ZNF385A;ZNF420", "intact": "RB1[20871633]|RPL5[22653443]|NOC2L[16322561]|RBPJ[26302407]|PSMD5[22653443]|MYC[21150319]|PSMD2[22653443]|DLEU1[16169070]|DDX17[15660129]|MED1[15848166]|DAXX[16845383;14557665;15364927;25241761;21134643]|PRKAB2[27107012]|CSNK2A1[22975381;25241761]|CSNK2A2[22653443]|PRKCD[16377624]|SCAMP1[16713569]|BCR[16169070;25241761]|FCAMR[21988832]|AR[19481544]|WDR82[23870121]|PSME3[18309296]|MAP1B[18656471]|PARD3[22653443]|ATF3[16169070]|TSPYL4[22653443]|PADI1[25402006]|ZNF24[16169070]|PLCG2[25814554]|PCDHA4[16169070]|SFN[20206173;21625211]|ATG7[22499945]|GSTM4[16169070]|BARD1[15782130]|TOE1[19508870]|CREBBP[10823891;9194564;10196247;25314079;19234109;19805293]|JUN[25609649]|PLK1[16753148;19833129;22653443]|SETD1A[23870121]|MAD2L1BP[16169070]|NFATC1[25609649]|NR0B2[22575647]|PHC3[27705803]|MOV10[25609649]|HNRNPK[21821029;23092970]|NMT1[16530191]|SNAI1[20385133]|NMT2[16530191]|FXYD6[16169070]|CDKN1A[16616141;21900206;25241761]|WDR48[19615732]|PHF1[27705803]|SETD7[15525938;21988832;16415881;17108971;17805299;21245319]|ASH2L[23870121;19433796]|SMG7[22653443]|GLI1[25609649]|SMG5[22653443;25609649]|ING4[15251430]|IKBKB[19883646;19196987]|ING2[16782091]|TMSB4X[16169070]|PBK[17482142;20622899]|ANXA7[21900206]|TK1[16169070;21900206]|NINL[26638075]|APPL1[25814554]|OFD1[26638075]|RING1[29187402]|ANXA3[16169070]|SERPINB9[16169070]|NUDT16L1[22653443]|SIRT1[11672523;17964266;12006491;15205477;18235501;18235502;21245319]|GNL3[12464630]|WDR33[16169070]|NCOR2[24449765]|KAT2B[16959611]|TUBB2C[22653443]|TUBB2A[22653443]|TCP1[22653443]|PAFAH1B3[16169070]|RNASEL[25609649]|HTT[10823891]|KIAA0087[16169070]|DLST[29128334]|WRN[11427532;15735006]|FOXS1[25609649]|SULT1E1[16169070]|TP53TG1[16169070]|RPS3[19656744]|STX5[16169070]|CCL18[16169070]|BRD7[20228809;20660729]|RPS27A[22653443]|WWOX[15580310]|EGLN3[26972000]|CDKN2C[16169070]|HSPA1L[17184779;25241761]|CDKN2A[12740913;22653443]|SYVN1[17170702]|GTF2H1[18354501]|HIPK1[12702766]|HIPK3[23602568]|HIPK2[15896780;16212962;21057547]|HINFP[21516116]|RYBP[19098711]|CCDC8[22653443]|PSMC1[22653443]|RFWD3[20173098]|HSPA1A[25241761]|CSE1L[17719542]|CEP120[26638075]|PLOD3[22653443]|SAT1[16169070]|CEP128[26638075]|FOXQ1[25609649]|YY1[25402006]|PPP1CC[17274640]|STK11[21317932]|MAEA[22653443]|YY2[25402006]|TUBB3[22653443]|MEN1[15960975]|PIAS4[11388671]|USP7[11923872;16845383;17268548;21170034;22653443;15916963;16402859;16474402;22056774]|SNRPN[16169070]|CEP135[26638075]|RPS7[17310983]|S100A2[20591429]|FBXW8[22653443;25609649]|S100A1[20591429]|SPICE1[26638075]|UBE2E1[29187402]|VRK1[15542844;24492002;29340707]|POLRMT[25609649]|FBXO11[17098746]|PIAS2[18624398;25241761]|RNF40[19410543]|PIAS1[15133049;25241761]|RBX1[22653443]|FOXP1[25609649]|NCL[22103682]|S100A6[20591429]|ERH[16169070]|MAPKAPK5[17254968]|S100A4[19740107;20591429;23752197]|S100A8[16169070]|CUL9[18230339;22653443;25609649]|KMT2E[21423215]|KHDRBS1[22653443]|CUL7[17298945;22653443;25609649]|BLM[22653443]|KMT2A[15960975]|ARL3[16169070]|KMT2C[19433796]|PHB[16319068;20134482;24380853]|FOXO3[14976264;25241761]|NPAS3[25609649]|RAP1B[21900206]|BAG6[22653443]|BAG2[22653443;25036637]|BTBD2[16169070]|BAG1[25036637]|DVL2[16189514;16713569;27107012]|SAFB2[21130767]|SMYD2[25609649;17805299;21782458]|SMN1[21900206]|MPDZ[22653443]|ZNF420[20713054]|IP6K2[21078964]|RAB4A[16169070]|NRDC[22653443]|BMX[16186805]|EEF2[22653443]|FOXN1[25609649]|COPS4[22653443]|GNL3L[21132010]|BCL6[25402006]|SP1[15710382;21831840]|CDK2[25241761]|MDM2[14704432;8875929;15848166;15144954;16212962;12915590;16845383;11178989;17139261;17159902;17268548;17347673;17310983;17875722;18309296;10196247;18485870;19166840;19098711;19411066;20591429;20708156;21170087;21132010;21988832;21726810;22085928;22575647;22659184;22819825;22510990;22975381;22653443;25241761;23776060;19656744;25609649;16432196;17080083;17438265;17470788;18172499;18316739;19234109;19255450;20173098;21857681;24207125;24667498;29997244]|BCL2[19521340;12667443]|TDRD12[22653443]|PIN1[12397362;21741598;21900206;17906639]|MDM4[15604276;17875722;19521340;20515689;20705607;15916963;25609649;17080083;19255450;24667498]|BCL2L1[16151013;21900206;12667443;14963330;24814347]|PPP1R13B[21513714]|HSP90AB1[22939624]|LRRK2[24725412]|RASGRF1[16753148]|ARRB1[21857681]|TSPAN10[22653443]|PAGR1[19039327]|SUMO1[16732283;19684601;20534433]|SIN3A[10823891;11359905]|PPP1R13L[21513714;17906639;23623661;18275817]|SUMO2[20534433]|WDR5[15960975;23870121;19433796]|GPX2[21988832]|HSP90AA1[21460846]|KSR1[27086506]|TRAF1[22653443]|KSR2[27086506]|DUSP26[20562916]|PTBP3[22575643]|SARS2[22653443]|RRM2B[19015526]|NUMB[18172499]|CRK[25814554]|SSX2IP[26638075]|PPP1R15A[29109149]|CEBPB[16227626]|HDAC2[17805299]|HDAC3[16847267]|UHRF2[21952639]|HDAC1[16959611;20075864;25241761]|CXXC1[23870121]|FOXK2[25609649]|FOXK1[25609649]|RCHY1[17568776;20452352;21988832;19043414]|HDAC8[17721440]|PPM1G[22653443]|CDC42[16169070]|IFI16[11146555;21397192]|RBBP5[15960975;23870121;19433796]|RNF20[19410543]|CEP152[26638075]|FOXJ3[25609649]|CABLES1[11706030]|PML[12915590;21057547;12006491;25241761]|MTOR[19619545]|NIN[26638075]|RAD51[9380510]|CEBPZ[12534345]|STUB1[25036637]|TPT1[21081126;22451927]|SMARCAL1[22653443]|GFI1[23410974]|PPP2R2A[17245430]|CCAR2[18235501]|PNP[16169070]|HERC2[22653443]|KAT5[18485870]|TRIM28[20864041]|PPP2R1A[17245430;25241761]|CHEK2[10724175;15862297;18833288]|CHEK1[16511572]|TRIM24[19556538]|KAT8[16601686;15960975]|RCC1[21900206]|MAGEA2[20864041;16847267]|BTRC[19196987]|TP63[19345189;21741598]|SOX4[19234109]|SKP1[22653443]|SMARCC1[18303029]|ANK2[20195357]|CSNK1D[25241761]|CSNK1E[25241761]|JMJD6[24667498]|NEIL3[25402006]|MT1A[16442532]|THAP8[16169070]|PPA1[16169070]|CSNK2B[22653443]|TP53[16291740;17612295;19339993;21988832;21522129;22653443;14985081;25609649;25402006;16461914;17620598;18087040;19667193;20004160;20159469;20364130;21178074;22972749]|OBSL1[22653443;25609649]|PAXIP1[19433796]|FOXG1[25609649]|TWIST2[22975381]|TWIST1[18504427;22975381;25402006]|NUAK1[21317932]|APOH[18624398]|TP53BP2[8875926;21513714;14985081;18275817]|TP53BP1[11877378;22653443;14985081;17805299;19433796;25579814;25651062;25837623]|MAGEC2[20864041]|BANP[20075864]|EGR1[14744935]|XRCC6[15782130]|GADD45A[21900206]|SMARCA5[25609649]|EAF2[27107012]|XRCC1[15044383]|PYCR3[22653443]|PTK2[15855171;19857493;25241761]|SMARCA4[18303029]|SRPK1[21130767]|ICK[23602568]|CCT6A[22653443]|AIMP2[18695251]|ATM[10864201]|GRB2[22653443]|ATR[16293623]|ZCCHC10[16169070]|CITED1[20227041]|OLA1[22653443]|BRCA1[9926942]|BRCA2[20421506]|XPO1[17268548;18952844]|ARIH2[16169070;22819825]|UFD1[21900206]|CCT3[22653443]|NCOA2[20195357]|SREBF1[22265415]|CCT2[22653443]|PARP1[12898523;14627987;15044383]|NCOA6[19433796]|TUBB[22653443]|MRPS22[22653443]|TOP3A[22653443]|TOPORS[17290218]|SREBF2[22265415]|FOXC1[25609649]|RABGAP1[22653443]|DKFZp434J046[22653443]|NEDD8[22653443]|CCDC106[16169070;20159018]|NOL3[18087040]|PES1[25609649]|LMNA[29568061]|CCT8[22653443]|CCT7[22653443]|CCT5[16169070;22653443]|DYNC1I1[16616141]|CCT4[22653443]|FOXB1[25609649]|NPM1[12080348;15144954;16376884]|NFYA[16959611]|NFYB[16959611;23734815]|HUWE1[15989956]|RPA1[15735006]|RANBP9[22653443]|RPA2[25609649]|MPP5[22653443]|APTX[15044383]|PPP1CA[15231748]|ITCH[16908849]|FOXA3[25609649]|MPHOSPH6[16169070]|OTUD5[19615732]|MAGEB18[16189514;16713569]|KDM1A[22653443;17805299]|UBE3A[16493710;12620801;26789255;29426014]|ETS2[26331536]|EP300[9194564;11907332;10518217;16782091;16611888;15542844;18485870;19339993;21471221;17906639;23010591;17438265;18391200;19217391;19234109;25651062;26302407]|RPGRIP1L[26638075]|ATAD3B[22653443]|ATAD3A[22653443]|HNRNPUL1[15907477;22653443]|FAM173A[16169070]|PPIF[22726440]|AIPL1[27173435;unassigned1312]|DDX5[20818423;15660129;24219989]|PSMD11[16169070]|RPS19BP1[17964266]|YTHDC2[22653443]|COX17[16169070]|STK4[25241761]|COP1[15103385;21625211]|UBB[17936559]|UBC[17139261;17170702;17159902;17268548;17290220;17568776;18309296;18388957;18566590;19098711;19619542;19536131;19798103]|HSPA9[17184779;20153329;22340593;22726440]|SMAD2[19345189;25241761;25670079]|UBE2I[15327968;18624398]|PDHA1[29128334]|HSPA5[17184779]|VDR[20227041]|EIF2S2[16169070]|CLK3[23602568]|NR4A1[17139261]|BMP1[18624398]|JMY[10518217]|BHLHE40[17347673;22723347]|MKRN1[19536131]|NABP1[25402006]|TCF4[25609649;25402006]|UBA1[29187402]|SAE1[15327968]|YWHAE[18812399]|GSK3B[14744935;21900206]|HSPB1[16169070;17184779;25241761]|HMGB1[9472015;23063560]|USP39[19615732]|YWHAQ[22653443]|ZIC3[25402006]|RB1CC1[21775823]|TOP1MT[25402006]|CASP1[11278253]|COLGALT1[22653443]|ZNF385A[17719541]|YWHAG[19933256;18812399;22653443]|GUSBP1[16169070]|TBP[7799929;9349482]|USP42[22085928]|TWNK[22653443]|AXIN1[21057547]|PPP2R5C[17245430;21460856;25241761]|SAFB[21130767]|YWHAZ[16376338;22653443]|CREB1[25241761]|OTUB1[22124327]|LAMA4[16169070;25241761]|USP11[19615732]|NT5C2[22653443]|AURKB[29340707]|HSPD1[22726440]|MAPK1[25241761]|DROSHA[24219989;19626115]|KDM4A[23871696]|NAP1L1[14966293]|S100B[20591429]|USP28[22653443]|USP29[21285945]|MAPK11[17254968]|NEURL4[22653443]|BAX[25241761]|" }, "interpro": { "all": [ [ "p53, tetramerisation domain", "P04637-7", "ENST00000504937" ], [ "p53, tetramerisation domain", "A0A087X1Q1", "ENST00000619186" ], [ "p53, tetramerisation domain", "P04637-4", "ENST00000610292" ], [ "p53, tetramerisation domain", "P04637", "ENST00000269305" ], [ "p53, tetramerisation domain", "P04637-4", "ENST00000620739" ], [ "p53, tetramerisation domain", "P04637", "ENST00000445888" ], [ "p53, tetramerisation domain", "P04637-4", "ENST00000619485" ] ], "domain": [ "p53, tetramerisation domain", "p53, tetramerisation domain", "p53, tetramerisation domain", "p53, tetramerisation domain", "p53, tetramerisation domain", "p53, tetramerisation domain", "p53, tetramerisation domain" ] }, "javierre_promoters": null, "linsight": null, "loftool": { "loftool_score": 0.000965 }, "lrt": { "lrt_converted_rankscore": 0.53742, "lrt_omega": 0.11836500000000001, "lrt_pred": "Damaging", "lrt_score": 0.00005 }, "metalr": { "bp4_benign": null, "pp3_pathogenic": "Moderate", 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"all": [ [ "AAGAB", " genetic interference ", "23284306", " \"synthetic growth defect sensu biogrid \" ", "1278703" ], [ "AARS", " affinity chromatography technology ", "32807901", " physical association ", "2976333" ], [ "AASDH", " bioid ", "38580884", " physical association ", "3713332" ], [ "AATF", " affinity chromatography technology ", "25996291", " physical association ", "2596577" ], [ "ABCA12", " genetic interference ", "24378760", " \"synthetic lethality sensu biogrid \" ", "3477142" ], [ "ABCF1", " affinity chromatography technology ", "32807901", " physical association ", "2976331" ], [ "ABCF2", " affinity chromatography technology ", "32807901", " physical association ", "2976524" ], [ "ABHD16B", " genetic interference ", "30862715", " \"negative genetic interaction sensu biogrid \" ", "2872157" ], [ "ABL1", " affinity chromatography technology ", "17992189", " physical association ", "3731298" ], [ "ABR", " affinity chromatography technology ", "23443559", " physical association ", "954635" ], [ "ABR", " affinity chromatography technology ", "32807901", " physical association ", "2976577" ], [ "ACACA", " affinity chromatography technology ", "31152661", " physical association ", "2659065" ], [ "ACAD10", " affinity chromatography technology ", "32807901", " physical association ", "2976787" ], [ "ACADM", " affinity chromatography technology ", "32807901", " physical association ", "2976655" ], [ "ACBD3", " affinity chromatography technology ", "32807901", " physical association ", "2976206" ], [ "ACKR3", " two hybrid ", "27229929", " direct interaction ", "2380967" ], [ "ACLY", " affinity chromatography technology ", "32807901", " physical association ", "2976172" ], [ "ACO2", " affinity chromatography technology ", "35140242", " physical association ", "3321365" ], [ "ACSL4", " affinity chromatography technology ", "23443559", " physical association ", "954636" ], [ "ACTA2", " affinity chromatography technology ", "23443559", " physical association ", "954638" ], [ "ACTB", " affinity chromatography technology ", "23443559", " physical association ", "954641" ], [ "ACTB", " affinity chromatography technology ", "25144556", " physical association ", "1029304" ], [ "ACTB", " affinity chromatography technology ", "35474131", " physical association ", "3638467" ], [ "ACTBL2", " affinity chromatography technology ", "25144556", " physical association ", "1029305" ], [ "ACTG1", " affinity chromatography technology ", "32807901", " physical association ", "2976274" ], [ "ACTL6A", " affinity chromatography technology ", "17878219", " physical association ", "658087" ], [ "ACTN4", " affinity chromatography technology ", "32807901", " physical association ", "2976565" ], [ "ACVR1C", " genetic interference ", "23284306", " \"synthetic growth defect sensu biogrid \" ", "1278704" ], [ "ADAM28", " genetic interference ", "23284306", " \"synthetic growth defect sensu biogrid \" ", "1278705" ], [ "ADAM9", " affinity chromatography technology ", "32807901", " physical association ", "2976606" ], [ "ADAR", " affinity chromatography technology ", "32807901", " physical association ", "2976389" ], [ "ADCK5", " affinity chromatography technology ", "32807901", " physical association ", "2976176" ], [ "ADD1", " affinity chromatography technology ", "32807901", " physical association ", "2976610" ], [ "ADD3", " affinity chromatography technology ", "32807901", " physical association ", "2976217" ], [ "ADH5", " affinity chromatography technology ", "20308539", " physical association ", "438249" ], [ "ADNP", " affinity chromatography technology ", "32807901", " physical association ", "2976456" ], [ "ADNP", " bioid ", "34795231", " physical association ", "3338713" ], [ "ADO", " genetic interference ", "38580884", " \"synthetic rescue sensu biogrid \" ", "3712957" ], [ "AGBL2", " affinity chromatography technology ", "20308539", " physical association ", "438250" ], [ "AGGF1", " affinity chromatography technology ", "33069768", " physical association ", "3196702" ], [ "AGO1", " affinity chromatography technology ", "20308539", " physical association ", "438259" ], [ "AGO1", " affinity chromatography technology ", "32807901", " physical association ", "2976587" ], [ "AGO2", " affinity chromatography technology ", "20308539", " physical association ", "438260" ], [ "AGO2", " affinity chromatography technology ", "32807901", " physical association ", "2976574" ], [ "AGPAT6", " affinity chromatography technology ", "32807901", " physical association ", "2976649" ], [ "AGT", " two hybrid ", "22416758", " direct interaction ", "643047" ], [ "AGTPBP1", " affinity chromatography technology ", "32807901", " physical association ", "2976178" ], [ "AGTRAP", " affinity chromatography technology ", "32807901", " physical association ", "2976561" ], [ "AHCTF1", " affinity chromatography technology ", "32807901", " physical association ", "2976836" ], [ "AHCY", " affinity chromatography technology ", "34591612", " physical association ", "3496461" ], [ "AHCY", " affinity chromatography technology ", "37438558", " physical association ", "3739025" ], [ "AIFM1", " affinity chromatography technology ", "32807901", " physical association ", "2976346" ], [ "AIFM2", " affinity chromatography technology ", "23443559", " physical association ", "954647" ], [ "AIMP2", " affinity chromatography technology ", "18695251", " physical association ", "327648" ], [ "AIMP2", " pull down ", "18695251", " direct interaction ", "327649" ], [ "AIMP2", " two hybrid ", "18695251", " direct interaction ", "327650" ], [ "AIP", " bioid ", "38580884", " physical association ", "3713457" ], [ "AIPL1", " affinity chromatography technology ", "27173435", " physical association ", "2332108" ], [ "AKAP12", " affinity chromatography technology ", "23443559", " physical association ", "954648" ], [ "AKAP5", " two hybrid ", "31182485", " direct interaction ", "2878990" ], [ "AKAP8L", " affinity chromatography technology ", "32807901", " 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